Lass J H, Langston R H, Foster C S, Pavan-Langston D
Antiviral Res. 1984 Jun;4(3):143-57. doi: 10.1016/0166-3542(84)90014-7.
Masked controlled rabbit studies were done to determine the toxic effects on corneal wound healing of the antiviral ointments 0.5% idoxuridine, 3% Ara A, and 3% acyclovir, and the antiviral drops 0.1% idoxuridine, 3% Ara AMP, and 1% trifluridine. Ara A, acyclovir, trifluridine and idoxuridine drops had no significant effects on the rate of closure of epithelial wounds. Idoxuridine ointment given 5 times a day significantly retarded the rate of epithelial wound closure, but not when given 4 times a day. Only Ara AMP caused a retardation of epithelial healing and an actual increase in the defect after 4 days of treatment. Histopathologically all drugs, except acyclovir, showed a toxic effect on the regenerating epithelium. All drugs, except acyclovir, showed retarded stromal wound healing with reduced bursting strength and collagen content. Ara AMP had increased bursting strength and collagen content possibly because of greater inflammation. Acyclovir, in comparison to all the other medications studied, appeared to have minimal to no toxic effects on experimental epithelial and stromal wound healing, and on this basis is the agent of choice for use in herpes simplex stromal keratitis with ulceration and as a prophylactic agent for long-term use after penetrating keratoplasty.
进行了遮蔽对照兔研究，以确定0.5%碘苷、3%阿糖腺苷和3%阿昔洛韦抗病毒软膏以及0.1%碘苷、3%阿糖腺苷单磷酸和1%三氟尿苷抗病毒滴眼液对角膜伤口愈合的毒性作用。阿糖腺苷、阿昔洛韦、三氟尿苷和碘苷滴眼液对上皮伤口的闭合速率没有显著影响。每天给药5次的碘苷软膏显著延缓上皮伤口的闭合速率，但每天给药4次时则无此现象。仅阿糖腺苷单磷酸在治疗4天后导致上皮愈合延迟且缺损实际增大。组织病理学上，除阿昔洛韦外，所有药物均对再生上皮显示出毒性作用。除阿昔洛韦外，所有药物均显示基质伤口愈合延迟，破裂强度和胶原蛋白含量降低。阿糖腺苷单磷酸的破裂强度和胶原蛋白含量增加，可能是由于炎症反应更强烈。与所研究的所有其他药物相比，阿昔洛韦对实验性上皮和基质伤口愈合似乎具有最小至无毒性作用，基于此，它是单纯疱疹性基质性角膜炎伴溃疡时的首选药物，也是穿透性角膜移植术后长期使用的预防药物。
