Ehrlich B E, Diamond J M
Am J Physiol. 1979 Jul;237(1):C102-10. doi: 10.1152/ajpcell.1979.237.1.C102.
The contribution of four transport pathways to Li+ influx and efflux in human erythrocytes was determined quantitatively, using Li+ concentrations comparable to those found in vivo when Li+ is used as treatment for manic-depressive illness. All pathways were measured simultaneously on each subject's blood sample to avoid possible temporal variations in transport parameters. We found that Li+ efflux is 75% via countertransport and 25% via a leak. The bicarbonate-sensitive pathway accounts for 30% of influx while the remaining 70% is via a leak. The Na+-K+ pump makes no significant contribution to Li+ influx or efflux under physiological conditions. Li+ efflux for a given [Li+]i is 3-5 times the Li+ influx for the same [Li+]o. However, due to interindividual variations in Na+-Li+ counter-transport, Li+ efflux but not influx varies considerably among individuals.
利用与锂用作躁郁症治疗时体内发现的浓度相当的锂离子浓度，定量测定了四种转运途径对人红细胞中锂离子流入和流出的贡献。在每个受试者的血样上同时测量所有途径，以避免转运参数可能出现的时间变化。我们发现，锂离子流出的75%通过逆向转运，25%通过渗漏。对碳酸氢盐敏感的途径占流入的30%，其余70%通过渗漏。在生理条件下，钠钾泵对锂离子的流入或流出没有显著贡献。对于给定的细胞内锂离子浓度，锂离子流出是相同细胞外锂离子浓度下锂离子流入的3至5倍。然而，由于钠锂逆向转运的个体差异，锂离子流出在个体之间差异很大，而流入则不然。
