Norris C P, Barnes G E, Smith E E, Granger H J
Am J Physiol. 1979 Aug;237(2):H174-7. doi: 10.1152/ajpheart.1979.237.2.H174.
Pressure-flow relations in the intestinal vasculature were obtained by producing stepwise reductions of intestinal perfusion pressure with an adjustable metal clamp placed upon the descending thoracic aorta. To eliminate intervention of the baroreceptor reflex, systemic arterial pressure was maintained constant by a pressure compensation system connected to the two carotid arteries. In the fed dogs, autoregulatory vasodilatory responses to reduced perfusion pressure maintained flow within 5% of control in the 85-125 mmHg range. In 30% of the fed dogs, superior mesenteric flow actually increased as perfusion pressure was reduced in the pressure range 85-125 mmHg, indicating superregulation of flow in the intestinal vasculature. The degree of flow autoregulation in the fasted dog was less than in the fed dog. Moreover, superregulation of intestinal flow was not observed in any of the fasted animals. These data suggest an intimate link between parenchymal activity and local flow control in the small intestine.
通过用置于降主动脉上的可调节金属夹逐步降低肠灌注压，来获得肠血管系统中的压力-流量关系。为消除压力感受器反射的干预，通过连接到两条颈动脉的压力补偿系统使体动脉压保持恒定。在喂食的狗中，对降低的灌注压的自动调节性血管舒张反应使流量在85 - 125 mmHg范围内维持在对照值的5%以内。在30%的喂食狗中，当灌注压在85 - 125 mmHg范围内降低时，肠系膜上动脉血流实际上增加了，这表明肠血管系统中存在流量的超调节。禁食狗的血流自动调节程度低于喂食狗。此外，在任何禁食动物中均未观察到肠血流的超调节。这些数据表明小肠实质活动与局部血流控制之间存在密切联系。
