Gottlieb M H, Eanes E D
Biophys J. 1972 Nov;12(11):1533-48. doi: 10.1016/s0006-3495(72)86180-0.
Over a wide range of water contents, aqueous lecithin-water mixtures are mesophases in which lecithin bilayers alternate with water layers. This paper reports on low-angle X-ray diffraction measurements of the effects of electrolytes, at 1.0 N concentration, on the thicknesses of the bilayers in mesophases formed by the synthetic lecithin: 1-octadec-9-enyl-2-hexadecylglycerophosphocholine. With solutions of LiCl, NaCl, Na(2)SO(4), KCl, and CsCl, the bilayer thicknesses are less than with pure water. The maximum reduction in bilayer thickness with these electrolytes is about 10% and occurs with mesophases of high content of KCl and CsCl solutions. With HCl solutions the bilayer thicknesses are about 5% greater than with pure water, and with CaCl(2) solutions the bilayer thicknesses are about the same as with pure water. The maximum amount of solution which can be mixed with lecithin before a second, purely aqueous phase is formed is also affected by electrolytes, the order for the various 1.0 N solutions being CsCl = KCl > NaCl > Na(2)SO(4) > (pure water) = LiCl > CaCl(2).
在很宽的含水量范围内，水相卵磷脂 - 水混合物是中间相，其中卵磷脂双层与水层交替排列。本文报道了在1.0 N浓度下，电解质对由合成卵磷脂1 - 十八碳 - 9 - 烯基 - 2 - 十六烷基甘油磷酸胆碱形成的中间相中双层厚度影响的低角度X射线衍射测量结果。对于LiCl、NaCl、Na₂SO₄、KCl和CsCl溶液，双层厚度比纯水时小。使用这些电解质时，双层厚度的最大减小约为10%，且在高含量KCl和CsCl溶液的中间相中出现。对于HCl溶液，双层厚度比纯水时大约大5%，而对于CaCl₂溶液，双层厚度与纯水时大致相同。在形成第二个纯液相之前，能够与卵磷脂混合的最大溶液量也受电解质影响，各种1.0 N溶液的顺序为CsCl = KCl > NaCl > Na₂SO₄ >（纯水）= LiCl > CaCl₂ 。
