肥胖高血糖小鼠（ob-ob）中的清除因子脂肪酶
Clearing-factor lipase in obese hyperglycaemic mice (ob-ob).
作者信息
Enser M
出版信息
Biochem J. 1972 Sep;129(2):447-53. doi: 10.1042/bj1290447.
Abstract
- Clearing-factor lipase was assayed in acetone-ether-dried powders of heart and epididymal fat-pads of lean and genetically obese mice (ob/ob). In both tissues the enzyme activity in the adult was higher in the obese mice. 2. In heart the enzyme activity was unchanged from 8 to 48 weeks of age in lean mice, but in obese mice it increased between 8 and 12 weeks of age and remained elevated. 3. Starvation produced changes in the heart clearing-factor lipase activity in obese, but not lean, mice. 4. The clearing-factor lipase activity of epididymal fat-pads decreased rapidly during 24h starvation in both lean and obese mice, but the activity in the obese mice remained higher than that in lean mice. 5. Plasma triglyceride and cholesterol concentrations were determined in both lean and obese mice. Triglyceride concentrations were not greatly different, but the obese mice were hypercholesterolaemic. Plasma cholesterol concentrations were not correlated with changes in clearing-factor lipase activity.
摘要
- 对瘦小鼠和遗传性肥胖小鼠（ob/ob）心脏及附睾脂肪垫的丙酮 - 乙醚干燥粉末中的清除因子脂肪酶进行了测定。在这两种组织中，成年肥胖小鼠的酶活性更高。2. 在瘦小鼠中，心脏中的酶活性在8至48周龄期间保持不变，但在肥胖小鼠中，其在8至12周龄之间增加并持续升高。3. 饥饿使肥胖小鼠而非瘦小鼠的心脏清除因子脂肪酶活性发生变化。4. 在瘦小鼠和肥胖小鼠中，附睾脂肪垫的清除因子脂肪酶活性在24小时饥饿期间均迅速下降，但肥胖小鼠中的活性仍高于瘦小鼠。5. 测定了瘦小鼠和肥胖小鼠的血浆甘油三酯和胆固醇浓度。甘油三酯浓度差异不大，但肥胖小鼠存在高胆固醇血症。血浆胆固醇浓度与清除因子脂肪酶活性的变化无关。
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