Nebreda V, Luzuriaga C, Igea J, Loridán L, Martul P
An Esp Pediatr. 1979 May;12(5):423-6.
Authors study forty eight children with severe lineal growth retardation. The more frequent causes of a stunted growth were ruled out previously (systemic and chronic diseases, metabolic disorders, genetic alterations, etc.). As a screening test, physical exercise was used to detect growth hormone (HGH) deficiency. A normal response was considered when HGH levels rose more than 7,0 ng./ml. after 20 minutes of continuous exercise. In those cases in which this level was not attained. insulin-hypoglycemia alone and followed by insulin plus an arginine infusion were used as stimuli, to confirm the lack of HGH response. A correct response to the exercise was found in 81% of the cases. It is concluded that the physical exercise as HGH stimulus is a good screening test. It presents a high degree of confidence with some other qualities, mainly: little disturbances to the patients, a rapid performance, lack of unpleasant colateral effects, and the possibility that it can be carried out by sanitary non-medical personnel.
作者研究了48名严重线性生长迟缓的儿童。此前已排除生长发育迟缓的常见原因（全身性和慢性疾病、代谢紊乱、基因改变等）。作为一项筛查测试，采用体育锻炼来检测生长激素（HGH）缺乏症。当连续运动20分钟后HGH水平升高超过7.0 ng/ml时，被认为是正常反应。在未达到该水平的情况下，单独使用胰岛素低血糖，随后静脉输注胰岛素加精氨酸作为刺激物，以确认缺乏HGH反应。81%的病例对运动有正确反应。得出的结论是，将体育锻炼作为HGH刺激物是一项很好的筛查测试。它具有高度的可信度以及一些其他优点，主要包括：对患者干扰小、操作快速、没有不良副作用，并且卫生非医务人员也有可能进行该项测试。
