Chisin R, Perlman M, Sohmer H
Ann Otol Rhinol Laryngol. 1979 May-Jun;88(3 Pt 1):352-7. doi: 10.1177/000348947908800310.
The site of lesion in hearing loss following neonatal hyperbilirubinemia is unclear. Histopathological studies have implicated the brain stem auditory nuclei while other investigations have hinted at a lesion in the cochlea. In order to clarify this issue, attempts were made to record responses from the auditory pathway in 13 patients with hearing loss following neonatal hyperbilirubinemia. The neural response from the auditory nerve was absent in 11 of the 13 patients and present only in response to high intensity stimuli in 2 patients. However, the response of the cochlear hair cells (cochlear microphonic potential) was present in 9 of the 13 patients. In most other cases of sensorineural hearing loss, with no history of hyperbilirubinemia, the hair cell response was absent. This is functional evidence for auditory nerve damage in cases of hearing loss following neonatal hyperbilirubinemia while the hair cells are spared.
新生儿高胆红素血症所致听力损失的病变部位尚不清楚。组织病理学研究认为病变部位在脑干听觉核，而其他研究则暗示病变在耳蜗。为了阐明这个问题，我们对13例新生儿高胆红素血症所致听力损失患者的听觉通路反应进行了记录。13例患者中有11例听神经无神经反应，仅2例在高强度刺激下有反应。然而，13例患者中有9例耳蜗毛细胞有反应（耳蜗微音器电位）。在大多数其他无高胆红素血症病史的感音神经性听力损失病例中，毛细胞无反应。这是新生儿高胆红素血症所致听力损失时听神经受损而毛细胞未受损的功能证据。
