Wilson S Z, Martin R R, Putman M, Greenberg S B, Wallace R J, Jemsek J G
Antimicrob Agents Chemother. 1979 Mar;15(3):379-83. doi: 10.1128/AAC.15.3.379.
Serial quantitative nasal cultures were performed on 87 healthy nasal carriers of Staphylococcus aureus, who were randomly assigned to 7 days of oral therapy with erythromycin, rosamicin (an investigational macrolide antibiotic), or placebo. Staphylococcal carrier rates decreased during therapy with both antibiotics; however, erythromycin was significantly more effective in lowering carrier rates than was rosamicin. The anti-staphylococcal effects of both antibiotics were similar when the mean numbers of S. aureus isolated from positive cultures during therapy were compared. Side effects to each regimen were minimal.
对87名健康的金黄色葡萄球菌鼻腔携带者进行了系列定量鼻腔培养，这些携带者被随机分配接受为期7天的口服红霉素、罗沙米星（一种研究中的大环内酯类抗生素）或安慰剂治疗。在使用这两种抗生素治疗期间，葡萄球菌携带率均下降；然而，红霉素在降低携带率方面比罗沙米星显著更有效。当比较治疗期间从阳性培养物中分离出的金黄色葡萄球菌的平均数量时，两种抗生素的抗葡萄球菌作用相似。每种治疗方案的副作用都很小。
