去甲麻黄碱作为人体尿液中（14C）苯丙胺的代谢产物。
Norephedrines as metabolites of ( 14 C)amphetamine in urine in man.
作者信息
Caldwell J, Dring L G, Williams R T
出版信息
Biochem J. 1972 Aug;129(1):23-4. doi: 10.1042/bj1290023.
Abstract
(+/-)-[(14)C]Amphetamine sulphate (20mg) was administered orally to each of two human male subjects, and 80-85% of the (14)C was excreted in the urine in 2 days. The metabolites in the first day's urine were examined quantitatively. Apart from the metabolites previously described (Dring et al., 1970), norephedrine (2.2 and 2.6% of dose in the two subjects respectively) and 4-hydroxynorephedrine (0.3 and 0.4% of dose in the two subjects respectively) were also found.
摘要
给两名男性人体受试者口服（±）-[(14)C]硫酸苯丙胺（20毫克），两天内80 - 85%的（14）C经尿液排出。对第一天尿液中的代谢产物进行了定量检测。除了之前描述过的代谢产物（德林等人，1970年）外，还发现了去甲麻黄碱（两名受试者分别占剂量的2.2%和2.6%）和4-羟基去甲麻黄碱（两名受试者分别占剂量的0.3%和0.4%）。
相似文献
1
Norephedrines as metabolites of ( 14 C)amphetamine in urine in man.去甲麻黄碱作为人体尿液中（14C）苯丙胺的代谢产物。
Biochem J. 1972 Aug;129(1):23-4. doi: 10.1042/bj1290023.
2
The metabolic fate of amphetamine in man and other species.安非他命在人类及其他物种中的代谢归宿。
Biochem J. 1970 Feb;116(3):425-35. doi: 10.1042/bj1160425.
3
Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat.人、豚鼠和大鼠体内（14C）甲基苯丙胺的代谢
Biochem J. 1972 Aug;129(1):11-22. doi: 10.1042/bj1290011.
4
The fate of amphetamine and norephedrine in the Tamarin monkey compared with man.与人类相比，塔马林猴体内苯丙胺和去甲麻黄碱的代谢情况。
West Afr J Pharmacol Drug Res. 1975 Jun;2(1):26-30.
5
Species differences in the metabolism of norephedrine in man, rabbit and rat.去甲麻黄碱在人、兔和大鼠体内代谢的种属差异。
Biochem J. 1973 Nov;136(3):763-71. doi: 10.1042/bj1360763.
6
Onthe presence of p-hydroxynorephedrine in the rat brain and heart in relation to changes in catecholamine levels after administration of amphetamine.关于苯丙胺给药后大鼠脑和心脏中对羟基去甲麻黄碱的存在与儿茶酚胺水平变化的关系。
Acta Pharmacol Toxicol (Copenh). 1971;29(1):3-48.
7
Metabolism and excretion of diethylpropion in man under acidic urine conditions.酸性尿液条件下人体中二乙丙醇胺的代谢与排泄
J Pharm Pharmacol. 1973 Feb;25(2):119-24. doi: 10.1111/j.2042-7158.1973.tb10604.x.
8
Displacement of brain and heart noradrenaline by p-hydroxynorephedrine after administration of p-hydroxyamphetamine.对羟基苯丙胺给药后，对羟基去甲麻黄碱对脑和心脏去甲肾上腺素的置换作用。
Acta Pharmacol Toxicol (Copenh). 1971;29(1):20-32. doi: 10.1111/j.1600-0773.1971.tb00579.x.
9
Urinary excretion of amphetamine in man after administration of prenylamine.服用心可定后人体中苯丙胺的尿排泄情况。
Life Sci. 1969 Mar 1;8(5):247-57. doi: 10.1016/0024-3205(69)90274-4.
10
[Pharmacokinetics of (-)-, (+)- and (+/-)-norephedrine. Plasma concentrations, serum protein binding and urinary excretions].（-）-、（+）-和（±）-去甲麻黄碱的药代动力学。血浆浓度、血清蛋白结合率及尿排泄情况
Yakugaku Zasshi. 1998 Apr;118(4):143-9. doi: 10.1248/yakushi1947.118.4_143.
引用本文的文献
1
Enantioselective Quantification of Amphetamine and Metabolites in Serum Samples: Forensic Evaluation and Estimation of Consumption Time.血清样本中苯丙胺及其代谢物的对映体选择性定量分析：法医学评估与摄入时间估计
Metabolites. 2021 Aug 6;11(8):521. doi: 10.3390/metabo11080521.
2
Wastewater-based tracing of doping use by the general population and amateur athletes.基于废水追踪普通人群和业余运动员的兴奋剂使用情况。
Anal Bioanal Chem. 2018 Feb;410(6):1793-1803. doi: 10.1007/s00216-017-0835-3. Epub 2018 Jan 15.
3
Species differences in the metabolism of norephedrine in man, rabbit and rat.去甲麻黄碱在人、兔和大鼠体内代谢的种属差异。
Biochem J. 1973 Nov;136(3):763-71. doi: 10.1042/bj1360763.
4
The metabolism of amphetamine in dependent subjects.安非他明在依赖者体内的代谢。
Eur J Clin Pharmacol. 1973 Oct;6(3):177-80. doi: 10.1007/BF00558282.
5
Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat.人、豚鼠和大鼠体内（14C）甲基苯丙胺的代谢
Biochem J. 1972 Aug;129(1):11-22. doi: 10.1042/bj1290011.
6
Observations on the fate of adrenocorticotrophin in isolated rat adrenal-cell suspensions and the separation of an enriched adrenocorticotrophin-sensitive steroidogenic cell fraction.关于促肾上腺皮质激素在分离的大鼠肾上腺细胞悬液中的命运以及富含促肾上腺皮质激素敏感的类固醇生成细胞组分的分离的观察
Biochem J. 1972 Sep;129(2):23P-24P. doi: 10.1042/bj1290023pb.
7
Rats become acutely tolerant to cathine after amphetamine or cathinone administration.在给予苯丙胺或卡西酮后，大鼠对去甲伪麻黄碱会产生急性耐受性。
Psychopharmacology (Berl). 1990;101(1):126-31. doi: 10.1007/BF02253729.
8
The metabolism of (-)-ephedrine in man.（-）-麻黄碱在人体内的代谢
Eur J Clin Pharmacol. 1975 Dec 19;9(2-3):193-8. doi: 10.1007/BF00614017.
9
Comparative effects of d-amphetamine, l-amphetamine, and methylphenidate on mood in man.右旋苯丙胺、左旋苯丙胺和哌醋甲酯对人体情绪的比较影响。
Psychopharmacology (Berl). 1977 Jun 6;53(1):1-12. doi: 10.1007/BF00426687.
10
The synthesis of tritium-labelled human corticotropin of high specific radioactivity.高比放射性氚标记人促肾上腺皮质激素的合成。
Biochem J. 1977 Jul 1;165(1):169-71. doi: 10.1042/bj1650169.
本文引用的文献
1
The fate of ethyltin and diethyltin derivatives in the rat.三乙基锡和二乙基锡衍生物在大鼠体内的命运。
Biochem J. 1967 Dec;105(3):1261-7. doi: 10.1042/bj1051261.
2
Amphetamine abuse. Pattern and effects of high doses taken intravenously.苯丙胺滥用。静脉注射高剂量的模式及影响。
JAMA. 1967 Jul 31;201(5):305-9. doi: 10.1001/jama.201.5.305.
3
Effects of hydroxyamphetamine (paredrine) on the function of the sympathetic nervous system in normotensive subjects.羟苯丙胺（帕吉林）对血压正常受试者交感神经系统功能的影响。
J Pharmacol Exp Ther. 1967 Feb;155(2):288-95.
4
Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man.苯丙胺对酪胺升压反应的影响：人体中苯丙胺形成对羟基去甲麻黄碱的过程。
Clin Pharmacol Ther. 1970 Sep-Oct;11(5):656-64. doi: 10.1002/cpt1970115656.
5
The metabolic fate of amphetamine in man and other species.安非他命在人类及其他物种中的代谢归宿。
Biochem J. 1970 Feb;116(3):425-35. doi: 10.1042/bj1160425.
6
Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat.人、豚鼠和大鼠体内（14C）甲基苯丙胺的代谢
Biochem J. 1972 Aug;129(1):11-22. doi: 10.1042/bj1290011.
Zotero 插件