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Br J Cancer. 1972 Dec;26(6):461-5. doi: 10.1038/bjc.1972.63.
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Mouse skin tumor-initiating activity of 5-, 7-, and 12-methyl- and fluorine-substituted benz[a]anthracenes.5-、7-和12-甲基及氟取代苯并[a]蒽的小鼠皮肤肿瘤起始活性。
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Exceptional carcinogenic activity of benz[a]anthracene 3,4-dihydrodiol in the newborn mouse and the bay region theory.苯并[a]蒽-3,4-二氢二醇在新生小鼠中的超强致癌活性与湾区理论
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[Neonatal cancerogenesis with 7,12-dimethylbenz(alpha) anthracene (DMBA) and anamnestic immunological response to Swiss mice].[7,12-二甲基苯并(α)蒽（DMBA）诱导新生小鼠致癌作用及对瑞士小鼠的回忆性免疫反应]
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Low carcinogenicity of the K-region epoxides of 7-methylbenz(a)-anthracene and benz(a)anthracene in the mouse and rat.
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Caffeine inhibits excision of 7-bromomethylbenz (a) anthracene-DNA adducts from exponentially growing but not from stationary phase Chinese hamster cells.咖啡因抑制指数生长期的中国仓鼠细胞中7-溴甲基苯并(a)蒽-DNA加合物的切除，但对静止期细胞无此作用。
Nucleic Acids Res. 1978 Dec;5(12):4795-803. doi: 10.1093/nar/5.12.4795.

本文引用的文献

1
METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE BY RAT-LIVER HOMOGENATES.多环化合物的代谢。大鼠肝脏匀浆对7,12-二甲基苯并（α）蒽的代谢
Biochem J. 1965 Jun;95(3):780-7. doi: 10.1042/bj0950780.
2
Low carcinogenicity of the K-region epoxides of 7-methylbenz(a)-anthracene and benz(a)anthracene in the mouse and rat.
Proc Soc Exp Biol Med. 1967 Mar;124(3):915-9. doi: 10.3181/00379727-124-31885.
3
Theory of tumour initiation by chemical carcinogens: dependence of activity on structure of ultimate carcinogen.化学致癌物引发肿瘤的理论：活性对最终致癌物结构的依赖性。
Eur J Cancer (1965). 1968 Oct;4(5):493-506. doi: 10.1016/0014-2964(68)90005-4.
4
Structure and activity in chemical carcinogenesis: reactivity and carcinogenicity of 7-bromomethylbenz[alpha]anthracene and 7-bromomethyl-12-methylbenz[alpha]anthracene.
Eur J Cancer (1965). 1970 Oct;6(5):417-23. doi: 10.1016/0014-2964(70)90040-x.
5
Structure and activity in chemical carcinogenesis. Studies of variously substituted 7-bromomethylbenz(a)anthracenes.化学致癌作用中的结构与活性。对各种取代的7-溴甲基苯并(a)蒽的研究。
Eur J Cancer (1965). 1971 Oct;7(5):473-6. doi: 10.1016/0014-2964(71)90046-6.
6
Reaction of 7-bromomethylbenz(a)anthracene with nucleic acids, polynucleotides, and nucleosides.7-溴甲基苯并(a)蒽与核酸、多核苷酸和核苷的反应。
Biochemistry. 1971 Nov;10(23):4323-30. doi: 10.1021/bi00799a026.
7
Carcinogenicity of derivatives of 7,12-dimethylbenz(a)anthracene.7,12-二甲基苯并(a)蒽衍生物的致癌性
Cancer Res. 1971 Dec;31(12):1951-4.
8
[Activity of some bromomethylated aromatic hydrocarbons on the in vitro synthesis of DNA and RNA].[某些溴甲基化芳烃对DNA和RNA体外合成的活性]
Chem Biol Interact. 1972 Mar;4(4):223-31. doi: 10.1016/0009-2797(72)90017-8.
9
Effect of carcinogens on DNA. Action of 7-bromomethylbenz (a) anthracene.致癌物对DNA的影响。7-溴甲基苯并(a)蒽的作用。
Biochimie. 1972;54(1):18-24.
10
Liver and lung tumors in mice exposed at birth to 4-dimethylaminoazobenzene or its 2-methyl or 3'-methyl derivatives.出生时暴露于4-二甲基氨基偶氮苯或其2-甲基或3'-甲基衍生物的小鼠的肝脏和肺部肿瘤。
J Natl Cancer Inst. 1971 Sep;47(3):593-601.

某些苯并(a)蒽衍生物对新生小鼠的致癌活性。

Carcinogenic activity of some benz(a)anthracene derivatives in newborn mice.

作者信息

Roe F J, Dipple A, Mitchley B C

出版信息

Br J Cancer. 1972 Dec;26(6):461-5. doi: 10.1038/bjc.1972.63.

DOI:10.1038/bjc.1972.63
PMID:4647396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2008673/
Abstract

Equimolar doses of 7-methylbenz(a)anthracene and 3 of its derivatives were given to newborn male and female Swiss mice. All 4 substances tested increased the risk of tumour development compared with that seen in control mice given the vehicle, arachis oil, only.7-Methylbenz(a)anthracene itself was the most actively tumorigenic of the compounds studied, giving rise to subcutaneous sarcomata at the site of injection, and multiple lung tumours and liver tumours. 7-Bromomethyl-12-methylbenz(a)-anthracene was similarly active in the lung and liver but evoked fewer subcutaneous sarcomata. 7-Bromomethylbenz(a)anthracene was seemingly slightly less active than either 7-methylbenz(a)anthracene or 7-bromomethyl-12-methylbenz(a)anthracene. 4-Chloro-7-bromomethylbenz(a)anthracene exhibited only marginal activity in that it slightly increased the risk of liver tumour development in male mice.

摘要

将等摩尔剂量的7-甲基苯并(a)蒽及其3种衍生物给予新生的雄性和雌性瑞士小鼠。与仅给予赋形剂花生油的对照小鼠相比，所有4种受试物质均增加了肿瘤发生的风险。7-甲基苯并(a)蒽本身是所研究化合物中最具活性的致瘤物质，在注射部位引发皮下肉瘤、多发性肺肿瘤和肝肿瘤。7-溴甲基-12-甲基苯并(a)蒽在肺和肝中同样具有活性，但诱发的皮下肉瘤较少。7-溴甲基苯并(a)蒽的活性似乎略低于7-甲基苯并(a)蒽或7-溴甲基-12-甲基苯并(a)蒽。4-氯-7-溴甲基苯并(a)蒽仅表现出微弱的活性，即它略微增加了雄性小鼠肝肿瘤发生的风险。