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Antibodies in delayed hypersensitive rats specifically desensitized by an intravenous injection of various antigen doses.经静脉注射不同剂量抗原特异性脱敏的迟发型超敏反应大鼠体内的抗体。
Immunology. 1972 Dec;23(6):861-70.
2
Disappearance of the delayed hypersensitivity reaction after intravenous antigen injection in the rat and guinea pig.大鼠和豚鼠静脉注射抗原后迟发型超敏反应的消失。
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The effect of intravenous antigen on circulating monocytes in animals with delayed hypersensitivity.静脉注射抗原对迟发型超敏反应动物循环单核细胞的影响。
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Int Arch Allergy Appl Immunol. 1973;45(3):360-72.
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引用本文的文献

1
Migration inhibition of peritoneal exudate cells from sensitized and desensitized rats.致敏和脱敏大鼠腹腔渗出细胞的迁移抑制
Immunology. 1973 Aug;25(2):283-95.
2
Naturally occurring cellular and humoral immunity to teichoic acid in rats.大鼠体内对磷壁酸的天然细胞免疫和体液免疫。
Immunology. 1974 Oct;27(4):517-24.

本文引用的文献

1
Elimination of 131-I-labelled protein antigens from the circulation of the mouse.从小鼠循环系统中清除¹³¹-I标记的蛋白质抗原。
Immunology. 1960 Oct;3(4):289-95.
2
Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.蛋白质和抗体研究的微量方法。I. 用鞣酸和蛋白质处理的红细胞进行血凝和血凝抑制反应的程序及一般应用。
J Immunol. 1954 May;72(5):360-7.
3
Immunologic competence of thymectomized rats to several soluble and particulate antigens.胸腺切除大鼠对几种可溶性和颗粒性抗原的免疫能力。
Int Arch Allergy Appl Immunol. 1966;30(3):217-30. doi: 10.1159/000229807.
4
Thymus-marrow cell combinations. Synergism in antibody production.胸腺-骨髓细胞组合。抗体产生中的协同作用。
Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167-71. doi: 10.3181/00379727-122-31353.
5
Desensitization studies of delayed hypersensitivity, with special reference to the possible role of high-affinity antibodies.迟发型超敏反应的脱敏研究，特别提及高亲和力抗体的可能作用。
J Immunol. 1966 Jun;96(6):953-9.
6
Determination of avidity of anti-albumin antibodies in the mouse. Influence of the number of cells transferred on the quality of the secondary adoptive response.小鼠抗白蛋白抗体亲和力的测定。转移细胞数量对二次过继性反应质量的影响。
Immunology. 1969 Aug;17(2):189-98.
7
Studies on the effect of systemic administration of sensitizers in guinea-pigs with contact sensitivity to inorganic metal compounds. 3. The effect of immunosuppressive agents on enhancing the unresponsiveness of already sensitized animals and an investigation of the action of the epicutaneous test within twenty-four hours.对已对无机金属化合物产生接触敏感性的豚鼠进行全身性给予致敏剂的效果研究。3. 免疫抑制剂对增强已致敏动物无反应性的作用以及对24小时内皮肤试验作用的研究。
Clin Exp Immunol. 1969 Apr;4(4):423-34.
8
The influence of amount and avidity of persisting primary antibodies on the secondary response to human serum albumin in rabbits.持续存在的一抗的量和亲和力对兔对人血清白蛋白二次反应的影响。
Immunology. 1971 Sep;21(3):475-81.
9
Studies on the induction of immunological tolerance by antigen in guinea-pigs already sensitized to dinitrochlorobenzene.关于抗原对已致敏于二硝基氯苯的豚鼠诱导免疫耐受的研究。
Clin Exp Immunol. 1971 Jan;8(1):131-9.
10
Studies of 125I trace labeling of immunoglobulin G by chloramine-T.用氯胺 - T对免疫球蛋白G进行¹²⁵I微量标记的研究。
Immunochemistry. 1970 Nov;7(11):885-98. doi: 10.1016/0019-2791(70)90051-0.

经静脉注射不同剂量抗原特异性脱敏的迟发型超敏反应大鼠体内的抗体。

Antibodies in delayed hypersensitive rats specifically desensitized by an intravenous injection of various antigen doses.

作者信息

Jokipii L, Jokipii A M

出版信息

Immunology. 1972 Dec;23(6):861-70.

PMID:4648853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1408003/
Abstract

Rats with delayed hypersensitivity to bovine serum albumin (BSA) and diphtheria toxoid were specifically desensitized by an intravenous injection of BSA. The degree of desensitization was positively related to the dose of antigen. The 4-hour skin reactions to BSA were weaker, and the passive haemagglutinin titres, antigen-binding capacity and average avidity of the antibodies were lower in the desensitized rats than in controls. The suppression of delayed hypersensitivity was apparently not caused by increased circulating antibody activity, but by a cellular defect or a humoral blocking factor.

摘要

对牛血清白蛋白（BSA）和白喉类毒素有迟发型超敏反应的大鼠，通过静脉注射BSA进行特异性脱敏。脱敏程度与抗原剂量呈正相关。脱敏大鼠对BSA的4小时皮肤反应较弱，其被动血凝素滴度、抗体的抗原结合能力和平均亲和力均低于对照组。迟发型超敏反应的抑制显然不是由循环抗体活性增加引起的，而是由细胞缺陷或体液阻断因子所致。