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经静脉注射不同剂量抗原特异性脱敏的迟发型超敏反应大鼠体内的抗体。

Antibodies in delayed hypersensitive rats specifically desensitized by an intravenous injection of various antigen doses.

作者信息

Jokipii L, Jokipii A M

出版信息

Immunology. 1972 Dec;23(6):861-70.

PMID:4648853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1408003/
Abstract

Rats with delayed hypersensitivity to bovine serum albumin (BSA) and diphtheria toxoid were specifically desensitized by an intravenous injection of BSA. The degree of desensitization was positively related to the dose of antigen. The 4-hour skin reactions to BSA were weaker, and the passive haemagglutinin titres, antigen-binding capacity and average avidity of the antibodies were lower in the desensitized rats than in controls. The suppression of delayed hypersensitivity was apparently not caused by increased circulating antibody activity, but by a cellular defect or a humoral blocking factor.

摘要

对牛血清白蛋白（BSA）和白喉类毒素有迟发型超敏反应的大鼠，通过静脉注射BSA进行特异性脱敏。脱敏程度与抗原剂量呈正相关。脱敏大鼠对BSA的4小时皮肤反应较弱，其被动血凝素滴度、抗体的抗原结合能力和平均亲和力均低于对照组。迟发型超敏反应的抑制显然不是由循环抗体活性增加引起的，而是由细胞缺陷或体液阻断因子所致。

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Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.蛋白质和抗体研究的微量方法。I. 用鞣酸和蛋白质处理的红细胞进行血凝和血凝抑制反应的程序及一般应用。
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Int Arch Allergy Appl Immunol. 1966;30(3):217-30. doi: 10.1159/000229807.
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Thymus-marrow cell combinations. Synergism in antibody production.胸腺-骨髓细胞组合。抗体产生中的协同作用。
Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167-71. doi: 10.3181/00379727-122-31353.
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Desensitization studies of delayed hypersensitivity, with special reference to the possible role of high-affinity antibodies.迟发型超敏反应的脱敏研究，特别提及高亲和力抗体的可能作用。
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