关于抗原对已致敏于二硝基氯苯的豚鼠诱导免疫耐受的研究。
Studies on the induction of immunological tolerance by antigen in guinea-pigs already sensitized to dinitrochlorobenzene.
作者信息
Frey J R, de Weck A L, Geleick H
出版信息
Clin Exp Immunol. 1971 Jan;8(1):131-9.
When guinea-pigs showing a high degree of contact sensitivity to dinitrochlorobenzene (DNCB) were injected intravenously with a related hapten, dinitrobenzene sulphonic acid sodium salt (DNBSO), the animals became totally unresponsive for 1 to 4 days and remained thereafter in a state of diminished sensitivity, lasting for 8 weeks. No lasting total unresponsiveness was achieved by an additional intradermal injection of DNCB (or various variations thereof) performed 6 hr after the intravenous injection (`double shot' procedure), in contrast to what had been observed in the Neoarsphenamine and potassium dichromate system. The effect of the intravenous injection of DNBSO is attributed to a temporary disappearance of the sensitized lymphoid cells from the circulation, whereas the induction of a permanent unresponsiveness certainly requires some additional mechanism.
当对二硝基氯苯（DNCB）表现出高度接触敏感性的豚鼠静脉注射相关半抗原二硝基苯磺酸钠盐（DNBSO）时，动物会在1至4天内完全失去反应，此后一直处于敏感性降低的状态，持续8周。与新胂凡纳明和重铬酸钾系统中观察到的情况相反，在静脉注射后6小时进行额外的皮内注射DNCB（或其各种变体）（“双注射”程序），并未实现持久的完全无反应性。静脉注射DNBSO的效果归因于致敏淋巴细胞暂时从循环中消失，而诱导永久性无反应性肯定需要一些额外的机制。
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