Ylikoski J, Collan Y, Palva T
Arch Otolaryngol. 1979 Aug;105(8):486-91. doi: 10.1001/archotol.1979.00790200048010.
Utricle and horizontal semicircular canal ampulla removed during labyrinthectomy from 11 patients with advanced Meniere's disease were studied under light and electron microscope. In light microscopy the epithelium of both sensory areas appeared fairly normal. Many sensory cells revealed fluid-filled crescents at the nucleus and many cells were extensively vacuolated. Ultrastructurally, a part of the observations were apparently artifacts due to specimen handling; some were normal, age-related findings. Some changes were considered secondary to dilation of the endolymphatic space. True signs of degeneration, seldom seen in these specimens were intraepithelial cysts, necrotic cells, and dark homogeneous masses in the sensory epithelium and dilated nerve fibers in the subepithelial tissue. No general degeneration of the utricular macula or ampullar crista seems to occur in Meniere's disease.
对11例晚期梅尼埃病患者在迷路切除术中切除的椭圆囊和水平半规管壶腹进行了光镜和电镜研究。在光镜下，两个感觉区域的上皮看起来相当正常。许多感觉细胞在细胞核处显示出充满液体的新月形，并且许多细胞广泛空泡化。在超微结构上，部分观察结果显然是由于标本处理造成的假象；一些是正常的、与年龄相关的发现。一些变化被认为是内淋巴间隙扩张的继发结果。在这些标本中很少见到的真正退化迹象是上皮内囊肿、坏死细胞、感觉上皮中的深色均质团块以及上皮下组织中扩张的神经纤维。梅尼埃病似乎不会发生椭圆囊斑或壶腹嵴的普遍退化。
