四亲代卵融合衍生的AKR嵌合体中白血病的延迟。
The delay of leukaemia in tetraparental ovum fusion-derived AKR chimaeras.
作者信息
Barnes R D, Tuffrey M, Kingman J
出版信息
Clin Exp Immunol. 1972 Dec;12(4):541-5.
Abstract
The development of thymic lymphomas in inbred AKR mice is well established. Ovum fusion of the AKR with a normal and relatively tumour resistant strain has been achieved to obtain AKR:CBA/H/ chimaeras. The fact that unlike the parental AKR, three of six AKR:CBA/H/ chimaeras are alive and well at more than 68 weeks of age, records the delay and suggests the possible inhibition of lymphomas in this situation.
摘要
近交系AKR小鼠胸腺淋巴瘤的发生已得到充分证实。已实现将AKR与正常且相对抗瘤的品系进行卵融合，以获得AKR:CBA/H嵌合体。与亲代AKR不同的是，六只AKR:CBA/H嵌合体中有三只在68周龄以上仍存活且健康，这一事实记录了淋巴瘤发生的延迟，并表明在这种情况下淋巴瘤可能受到抑制。
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