Frati Munari A C, San Martin J A, Alanís F, Martínez-Cairo S
Bol Med Hosp Infant Mex. 1979 Sep-Oct;36(5):797-804.
In view of the fact that relatives of patient with other connective tissue diseases may show immunologic abnormalities, we investigated cellular (PPD, SK-SD, candidine and diphteria-tetanous toxoid cutaneous tests) and humoral (IgG, IgM, IgA. CH50, C3, rheumatoid factor and ANA) immune responses in first degrees relatives (parents and siblings) of children with dermatomyositis. Of the 53 subjects tested, 19 had high values of one or two immunoglobulines; however, the mean Ig value was not different from that of the general population (p greater than 0.1), CH50, C3, rheumatoid factor and ANA were normal or negative. Cutaneous tests made on 46 subjects did not reveal abnormalities. Therefore our conclusion is that first degree relatives of children with dermatomyositis have not significant immunologic abnormalities.
鉴于其他结缔组织疾病患者的亲属可能会出现免疫异常，我们对皮肌炎患儿的一级亲属（父母和兄弟姐妹）进行了细胞免疫（结核菌素纯蛋白衍生物、链球菌激酶-链道酶、白色念珠菌素和白喉破伤风类毒素皮肤试验）和体液免疫（免疫球蛋白G、免疫球蛋白M、免疫球蛋白A、总补体活性、补体3、类风湿因子和抗核抗体）反应的研究。在接受检测的53名受试者中，19人有一种或两种免疫球蛋白值偏高；然而，免疫球蛋白的平均水平与普通人群并无差异（p>0.1），总补体活性、补体3、类风湿因子和抗核抗体均正常或呈阴性。对46名受试者进行的皮肤试验未发现异常。因此，我们的结论是，皮肌炎患儿的一级亲属不存在明显的免疫异常。
