Marin J L, Orchard C, Chakrabarti M K, Sykes M K
Br J Anaesth. 1979 Apr;51(4):303-12. doi: 10.1093/bja/51.4.303.
The effects of dopamine and isoprenaline on the pulmonary vasoconstrictor response to alveolar hypoxia were assessed by measuring the redistribution of blood flow between the lungs in response to unilateral hypoxia. Dose rates of dopamine 25 micrograms kg-1 min-1 and isoprenaline 0.25 micrograms kg-1 min-1 (which produced equal increments in thecontractile force of the heart in dogs) produced a similar degree of depression of they hypoxic vasoconstrictor response, whereas dopamine 2.5 micrograms kg-1 min-1 had little effect on the response PaO2 during unilateral hypoxia was inversely related to the blood flow through the hypoxic lung.
通过测量单侧低氧时肺之间血流的重新分布，评估多巴胺和异丙肾上腺素对肺泡低氧引起的肺血管收缩反应的影响。多巴胺剂量率为25微克/千克·分钟和异丙肾上腺素剂量率为0.25微克/千克·分钟（这在犬类中使心脏收缩力产生相等的增量）产生了相似程度的低氧性血管收缩反应抑制，而多巴胺2.5微克/千克·分钟对该反应几乎没有影响。单侧低氧期间的动脉血氧分压（PaO2）与通过低氧肺的血流呈负相关。
