美托洛尔与氢氯噻嗪复方片剂及氢氯噻嗪单独给药的生物利用度和处置情况。
Bioavailability and disposition of metoprolol and hydrochlorothiazide combined in one tablet and of separate doses of hydrochlorothiazide.
作者信息
Jordö L, Johnsson G, Lundborg P, Persson B A, Regärdh C G, Rönn O
出版信息
Br J Clin Pharmacol. 1979 Jun;7(6):563-7. doi: 10.1111/j.1365-2125.1979.tb04643.x.
Abstract
- The plasma levels and the urinary excretion of hydrochlorothiazide (HCT) have been studied after administration of single doses of 12.5 and 25 mg of the drug in solution and in combination with 100 mg of the selective beta 1-adrenoreceptor antagonist metoprolol in a rapidly dissolving tablet. 2. Metoprolol did not significantly influence the bioavailability or the time-course of HCT. 3. HCT had no significant effect on the time-course or the plasma levels of metoprolol. The average half-life, 4.4 +/- 0.9 h, is about the same as previously observed for separate doses of this drug. 4. It seems unlikely that repeated doses of the combination product studied will lead to biopharmaceutic or pharmacokinetic interactions of clinical importance.
摘要
- 研究了单次服用12.5毫克和25毫克氢氯噻嗪（HCT）溶液剂以及与100毫克选择性β1肾上腺素能受体拮抗剂美托洛尔制成的速溶片后，HCT的血浆水平和尿排泄情况。2. 美托洛尔对HCT的生物利用度或时程没有显著影响。3. HCT对美托洛尔的时程或血浆水平没有显著影响。平均半衰期为4.4±0.9小时，与先前单独服用该药物时观察到的情况大致相同。4. 所研究的复方制剂重复给药似乎不太可能导致具有临床重要性的生物药剂学或药代动力学相互作用。
相似文献
1
Bioavailability and disposition of metoprolol and hydrochlorothiazide combined in one tablet and of separate doses of hydrochlorothiazide.美托洛尔与氢氯噻嗪复方片剂及氢氯噻嗪单独给药的生物利用度和处置情况。
Br J Clin Pharmacol. 1979 Jun;7(6):563-7. doi: 10.1111/j.1365-2125.1979.tb04643.x.
2
The effect of pretreatment with cimetidine on the bioavailability and disposition of atenolol and metoprolol.西咪替丁预处理对阿替洛尔和美托洛尔生物利用度及处置的影响。
Br J Clin Pharmacol. 1982 Jul;14(1):67-72. doi: 10.1111/j.1365-2125.1982.tb04935.x.
3
Comparative pharmacokinetic profiles of metoprolol and chlorthalidone administered alone or in combination to healthy volunteers.美托洛尔和氯噻酮单独或联合给药于健康志愿者的比较药代动力学特征。
Eur J Clin Pharmacol. 1983;24(5):655-60. doi: 10.1007/BF00542217.
4
Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered.
J Pharmacokinet Biopharm. 1984 Dec;12(6):575-86. doi: 10.1007/BF01059553.
5
A pharmacokinetic and pharmacodynamic assessment of a combined slow-release metoprolol-chlorthalidone preparation.
J Clin Hosp Pharm. 1981 Dec;6(4):259-65. doi: 10.1111/j.1365-2710.1981.tb01002.x.
6
Pharmacokinetics of mepindolol administered alone and in combination with hydrochlorothiazide--a bioequivalence study.美哌洛尔单独及与氢氯噻嗪联合给药的药代动力学——一项生物等效性研究。
Biopharm Drug Dispos. 1983 Oct-Dec;4(4):339-45. doi: 10.1002/bdd.2510040406.
7
Metoprolol kinetics and dose response in hypertensive patients.
Clin Pharmacol Ther. 1980 Jun;27(6):756-62. doi: 10.1038/clpt.1980.106.
8
The effect of food on the relative bioavailability of rapidly dissolving immediate-release solid oral products containing highly soluble drugs.食物对含有高溶解性药物的速溶即释固体口服制剂相对生物利用度的影响。
Mol Pharm. 2004 Sep-Oct;1(5):357-62. doi: 10.1021/mp0499407.
9
Pharmacokinetics of metoprolol in patients with hepatic cirrhosis.肝硬化患者中美托洛尔的药代动力学
Clin Pharmacokinet. 1981 Sep-Oct;6(5):375-88. doi: 10.2165/00003088-198106050-00004.
10
The pharmacokinetics and pharmacodynamics of metoprolol after conventional and controlled-release administration in combination with hydrochlorothiazide in healthy volunteers.美托洛尔在健康志愿者中常规给药和控释给药并联合氢氯噻嗪后的药代动力学和药效学。
Eur J Clin Pharmacol. 1993;45(2):161-3. doi: 10.1007/BF00315499.
引用本文的文献
1
A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration.联合使用 G 蛋白偶联受体调节剂可保护感光细胞免受变性损伤。
J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21.
2
Metoprolol succinate extended release/hydrochlorothiazide combination tablets.琥珀酸美托洛尔缓释片/氢氯噻嗪复方片剂
Vasc Health Risk Manag. 2007;3(3):279-88.
3
Approaches to meeting the criteria for fixed dose antihypertensive combinations. Focus on metoprolol.达到固定剂量抗高血压联合用药标准的方法。以美托洛尔为重点。
Drugs. 1995 Sep;50(3):454-64. doi: 10.2165/00003495-199550030-00004.
4
Fixed-dose combination antihypertensive drugs. Do they have a role in rational therapy?固定剂量复方抗高血压药物。它们在合理治疗中起作用吗？
Drugs. 1994 Jul;48(1):16-24. doi: 10.2165/00003495-199448010-00003.
5
Pharmacokinetics of metoprolol in patients with hepatic cirrhosis.肝硬化患者中美托洛尔的药代动力学
Clin Pharmacokinet. 1981 Sep-Oct;6(5):375-88. doi: 10.2165/00003088-198106050-00004.
6
Pharmacokinetics in man of acebutolol and hydrochlorothiazide as single agents and in combination.醋丁洛尔和氢氯噻嗪单药及联合用药在人体中的药代动力学。
Eur J Clin Pharmacol. 1983;24(6):801-6. doi: 10.1007/BF00607091.
7
Pharmacokinetics of hydrochlorothiazide in relation to renal function.氢氯噻嗪的药代动力学与肾功能的关系。
Eur J Clin Pharmacol. 1983;24(5):661-5. doi: 10.1007/BF00542218.
8
Pharmacokinetic and pharmacodynamic properties of metoprolol in patients with impaired renal function.美托洛尔在肾功能受损患者中的药代动力学和药效学特性。
Clin Pharmacokinet. 1980 Mar-Apr;5(2):169-80. doi: 10.2165/00003088-198005020-00004.
9
A comparative study of the pharmacokinetics and pharmacodynamics of atenolol, hydrochlorothiazide and amiloride in normal young and elderly subjects and elderly hypertensive patients.
Eur J Clin Pharmacol. 1987;32(1):53-60. doi: 10.1007/BF00609957.
本文引用的文献
1
The influence of dosage form on the activity of a diuretic agent.剂型对利尿剂活性的影响。
Clin Pharmacol Ther. 1968 Sep-Oct;9(5):598-604. doi: 10.1002/cpt196895598.
2
To be taken as directed.按指示服用。
J R Coll Gen Pract. 1968 Jul;16(1):39-44.
3
Propranolol and polythiazide in treatment of hypertension.普萘洛尔与苄噻嗪治疗高血压
Br Heart J. 1972 Oct;34(10):1042-4. doi: 10.1136/hrt.34.10.1042.
4
Effect of alprenolol on blood pressure and plasma renin activity in hypertensive patients.心得舒对高血压患者血压及血浆肾素活性的影响。
Acta Med Scand. 1973 Mar;193(3):189-95. doi: 10.1111/j.0954-6820.1973.tb10560.x.
5
Pharmacokinetic studies on the selective beta1-receptor antagonist metoprolol in man.人用选择性β1受体拮抗剂美托洛尔的药代动力学研究。
J Pharmacokinet Biopharm. 1974 Aug;2(4):347-64. doi: 10.1007/BF01061407.
6
Absorption, metabolism, and excretion of hydrochlorothiazide.氢氯噻嗪的吸收、代谢及排泄
Clin Pharmacol Ther. 1976 May;19(5 Pt 1):531-7. doi: 10.1002/cpt1976195part1531.
7
Hydrochlorothiazide.氢氯噻嗪
J Am Pharm Assoc. 1976 Jan;16(1):47-50.
8
Combined pharmacokinetic and pharmacodynammc studies in man of the adrenergic beta1-receptor antagonist metoprolol.肾上腺素能β1受体拮抗剂美托洛尔在人体中的药代动力学和药效学联合研究。
Acta Pharmacol Toxicol (Copenh). 1975;36(Suppl 5):31-44. doi: 10.1111/j.1600-0773.1975.tb03320.x.
9
Comparative bioavailability and effect studies on metoprolol administered as ordinary and slow-release tablets in single and multiple doses.美托洛尔普通片与缓释片单剂量及多剂量给药的比较生物利用度和效应研究。
Acta Pharmacol Toxicol (Copenh). 1975;36(Suppl 5):45-58. doi: 10.1111/j.1600-0773.1975.tb03321.x.
10
Quantitative determination of metoprolol in plasma and urine by gas chromatography.气相色谱法定量测定血浆和尿液中的美托洛尔。
Acta Pharmacol Toxicol (Copenh). 1975;36(Suppl 5):136-44. doi: 10.1111/j.1600-0773.1975.tb03330.x.
Zotero 插件