各种抗高血压药物对肾性高血压大鼠寿命的影响。
Influence of various antihypertensive agents on lifespan of renal hypertensive rats.
作者信息
Horovitz Z P, Antonaccio M J, Rubin B, Panasevich R E
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 2(Suppl 2):243S-248S. doi: 10.1111/j.1365-2125.1979.tb04696.x.
Abstract
1 Daily treatment of two-kidney clipped renal hypertensive rats with hydrallazine, hydrochlorothiazide (HCTZ) and a new orally active inhibitor of the angiotensin-converting enzyme, captopril (SQ14,225), was correlated with survival rates for up to 9 months. 2 The groups of rats given captopril alone or captopril plus intermittent or chronic HCTZ had the best survival rate, whereas HCTZ alone or hydrallazine did not benefically affect survival. 3 Survival rates correlated well with control of BP in these animals.
摘要
- 用肼苯哒嗪、氢氯噻嗪（HCTZ）和一种新的口服活性血管紧张素转换酶抑制剂卡托普利（SQ14,225）对两肾一夹肾性高血压大鼠进行每日治疗，并将其与长达9个月的存活率相关联。2. 单独给予卡托普利或卡托普利加间歇性或慢性HCTZ的大鼠组存活率最高，而单独使用HCTZ或肼苯哒嗪对存活率没有有益影响。3. 在这些动物中，存活率与血压控制密切相关。
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