醋酸环丙孕酮促进睾酮和加压素给药后肾皮质坏死的预防。
Cyproterone acetate-promoted prevention of renal cortical necrosis following testosterone and vasopressin administration.
作者信息
Mónus Z, László F A
出版信息
Br J Exp Pathol. 1979 Feb;60(1):72-5.
Abstract
Bilateral focal renal cortical necrosis was observed after vasopressin administration in rats pretreated for 10 days with testosterone phenyl propionate. When the androgen-receptor blocking-agent cyproterone acetate was administered together with the testosterone, the subsequent vasopressin treatment did not cause renal cortical necrosis. The results suggest the role of the androgen receptors in the kidney in the induction of the phenomenon.
摘要
在给用丙酸苯酯睾酮预处理10天的大鼠注射加压素后，观察到双侧局灶性肾皮质坏死。当雄激素受体阻断剂醋酸环丙孕酮与睾酮一起给药时，随后的加压素治疗并未引起肾皮质坏死。结果提示肾脏中的雄激素受体在该现象的诱导中起作用。
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