抗雌激素他莫昔芬对雌酮+加压素诱导的大鼠肾皮质坏死发展的影响。
Effect of the anti-oestrogen tamoxifen on the development of renal cortical necrosis induced by oestrone + vasopressin administration in rats.
作者信息
Kocsis J, Karácsony G, Karcsú S, László F A
机构信息
Department of Radiology, University Medical School, Szeged, Hungary.
出版信息
Br J Exp Pathol. 1988 Apr;69(2):157-67.
Bilateral renal cortical necrosis was observed after vasopressin administration in rats pretreated with oestrone acetate. Histochemical (succinic dehydrogenase, trichrome, periodic acid Schiff) and electronmicroscopic methods were used to examine how the anti-oestrogen, Tamoxifen, influences the development of this renal cortical necrosis. The experiments revealed that in most rats vasopressin did not induce renal tubular necrosis if the anti-oestrogen was administered simultaneously, even during oestrogen pretreatment. The results suggest that oestrogen receptors in the kidney are involved in the induction of renal cortical necrosis by vasopressin.
在给予醋酸雌酮预处理的大鼠血管加压素后，观察到双侧肾皮质坏死。采用组织化学方法（琥珀酸脱氢酶、三色染色、过碘酸希夫反应）和电子显微镜方法，研究抗雌激素药物他莫昔芬如何影响这种肾皮质坏死的发展。实验表明，在大多数大鼠中，如果同时给予抗雌激素药物，即使在雌激素预处理期间，血管加压素也不会诱发肾小管坏死。结果提示，肾脏中的雌激素受体参与了血管加压素诱导的肾皮质坏死过程。
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