Brownstein M H, Mehregan A H, Bikowski J B, Lupulescu A, Patterson J C
Br J Dermatol. 1979 Jun;100(6):667-73. doi: 10.1111/j.1365-2133.1979.tb08070.x.
During the past 2 years we have studied eighty-nine biopsy specimens from nineteen patients with Cowden's syndrome. Among fifty-three facial lesions, twenty-nine were trichilemmomas. Twenty-three of the others were consistent with trichilemmoma, showed a non-specific benign verrucous acanthoma, or were not diagnostic; one was a blue naevus. All fourteen oral mucosal biopsy specimens were benign fibromas. Nineteen of twenty-two biopsy specimens from the hands and feet showed the pattern of benign keratosis. Multiple trichilemmomas were found in all patients with Cowden's syndrome, but at times several biopsy specimens were required before a diagnostic picture was uncovered. All patients with multiple facial trichilemmomas were found to have Cowden's syndrome. The combination of multiple facial trichilemmomas, oral fibromas, and benign acral keratoses enables one to diagnose Cowden's syndrome at a stage before serious internal complications develop.
在过去两年中，我们研究了19例考登综合征患者的89份活检标本。在53处面部病变中，29处为毛发上皮瘤。其他病变中有23处符合毛发上皮瘤表现，呈现非特异性良性疣状棘皮瘤，或无法做出诊断；1处为蓝痣。所有14份口腔黏膜活检标本均为良性纤维瘤。22份手足活检标本中有19份显示良性角化病模式。所有考登综合征患者均发现有多发性毛发上皮瘤，但有时需要多份活检标本才能发现诊断性特征。所有有多发性面部毛发上皮瘤的患者均被发现患有考登综合征。多发性面部毛发上皮瘤、口腔纤维瘤和良性肢端角化病的组合使人们能够在严重的内部并发症出现之前诊断考登综合征。
