Hunter D J, Anderson A B, Haddon M
Br J Obstet Gynaecol. 1979 Jun;86(6):488-90. doi: 10.1111/j.1471-0528.1979.tb10795.x.
Coagulation factors II, VII, X, VII + X complex and anti-thrombin III were measured in 10 postmenopausal women before, during and after a four-month course of 20 microgram daily of ethinyl oestradiol, taken three weeks in four. Factors VII, X and VII + X complex rose significantly during treatment but only factor X levels were significantly elevated at the end of the four-month treatment period. There was no change in factor II or anti-thrombin III levels. These effects on coagulation factors during ethinyl oestradiol therapy are, in general, similar to those found during treatment with conjugated equine oestrogens and oestradiol valerate in a previous study from the same laboratory. It seems likely that equipotent doses of ethinyl oestradiol and 'natural' oestrogens have similar effects on these coagulation factors.
对10名绝经后女性在每日服用20微克炔雌醇（每四周服用三周）的四个月疗程之前、期间和之后，测量了凝血因子II、VII、X、VII + X复合物和抗凝血酶III。治疗期间因子VII、X和VII + X复合物显著升高，但仅在四个月治疗期结束时因子X水平显著升高。因子II或抗凝血酶III水平没有变化。炔雌醇治疗期间对凝血因子的这些影响，总体上与同一实验室之前一项研究中使用结合马雌激素和戊酸雌二醇治疗期间发现的影响相似。炔雌醇和“天然”雌激素的等效剂量似乎对这些凝血因子有相似的影响。
