双嘧达莫对去甲肾上腺素、异丙肾上腺素和腺苷的心肌血管舒张作用的影响。
The effects of dipyridamole on the myocardial vasodilator actions of noradrenaline, isoprenaline and adenosine.
作者信息
Parratt J R, Wadsworth R M
出版信息
Br J Pharmacol. 1972 Dec;46(4):585-93. doi: 10.1111/j.1476-5381.1972.tb06885.x.
Abstract
- In anaesthetized cats, intravenous adenosine infusions decreased resistance to blood flow in the myocardial vascular bed. This effect of adenosine was augmented during the 60 min following the intravenous injection of dipyridamole (1 mg/kg).2. In different experiments, intravenous infusions of noradrenaline caused either a slight increase or a slight decrease in myocardial vascular resistance. The dilator component of the action of noradrenaline was not augmented by dipyridamole.3. Isoprenaline infusions decreased the resistance of the myocardial bed. This effect was unaltered after dipyridamole.4. These results do not support the hypothesis that part of the effect of catecholamines on myocardial vascular resistance involves the release of adenosine from hypoxic myocardial cells.
摘要
在麻醉猫中，静脉输注腺苷可降低心肌血管床的血流阻力。在静脉注射双嘧达莫（1毫克/千克）后的60分钟内，腺苷的这种作用增强。
在不同实验中，静脉输注去甲肾上腺素可使心肌血管阻力略有增加或略有降低。双嘧达莫不会增强去甲肾上腺素作用的扩张成分。
输注异丙肾上腺素可降低心肌床的阻力。双嘧达莫对此作用无影响。
这些结果不支持以下假说：儿茶酚胺对心肌血管阻力的部分作用涉及缺氧心肌细胞释放腺苷。
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