关于睾酮对雄激素依赖性组织中蛋白质合成刺激作用的进一步研究。
Further studies on the stimulation of protein synthesis in androgen-dependent tissues by testosterone.
作者信息
Mainwaring W I, Wilce P A
出版信息
Biochem J. 1972 Nov;130(1):189-97. doi: 10.1042/bj1300189.
Abstract
- By using centrifugation through a discontinuous sucrose gradient, four microsomal fractions are obtained from the prostate gland. 2. Administration of androgens to castrated rats stimulates protein synthesis in all fractions, particularly in the heavy rough fraction. 3. Androgens also increase the content of protein, RNA and phospholipid in the heavy rough fraction. 4. Time-course experiments in vivo show that androgens induce a rapid increase in the synthesis of ribosomal precursor RNA preceding the synthesis of new microsomal fraction and the increase in protein synthesis.
摘要
- 通过在不连续蔗糖梯度中进行离心，可从前列腺获得四个微粒体组分。2. 给去势大鼠注射雄激素会刺激所有组分中的蛋白质合成，尤其是在重质粗面组分中。3. 雄激素还会增加重质粗面组分中蛋白质、RNA和磷脂的含量。4. 体内的时间进程实验表明，雄激素会在新微粒体组分合成和蛋白质合成增加之前，诱导核糖体前体RNA合成迅速增加。
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本文引用的文献
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Regulation of polyribosome formation and protein synthesis in the uterus. Effect of ovariectomy and administration of oestradiol-17beta on the amino acid-incorporation activity in vitro and the cytoplasmic concentration in vivo of polyribosomal preparation.子宫内多核糖体的形成和蛋白质合成的调节。卵巢切除术和 17β-雌二醇给药对体外氨基酸掺入活性和体内多核糖体制剂细胞质浓度的影响。
Biochem J. 1967 Dec;105(3):1101-9. doi: 10.1042/bj1051101.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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GROWTH HORMONE CONTROL OF BIOSYNTHESIS OF PROTEIN AND RIBONUCLEIC ACID.生长激素对蛋白质和核糖核酸生物合成的调控
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ENTRANCE OF NEWLY FORMED MESSENGER RNA AND RIBOSOMES INTO HELA CELL CYTOPLASM.新形成的信使核糖核酸和核糖体进入海拉细胞细胞质。
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TESTICULAR HORMONES AND THE SYNTHESIS OF RIBONUCLEIC ACIDS AND PROTEINS IN THE PROSTATE GLAND.睾丸激素与前列腺中核糖核酸和蛋白质的合成
Recent Prog Horm Res. 1964;20:247-301.
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An effect of testosterone on amino acid incorporation by prostatic ribonucleoprotein particles.睾酮对前列腺核糖核蛋白颗粒氨基酸掺入的影响。
Proc Natl Acad Sci U S A. 1962 Nov 15;48(11):1956-64. doi: 10.1073/pnas.48.11.1956.
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A tissue fractionation study of rat ventral prostate: subcellular distribution of nucleic acids, succinate oxidizing systems, cytochrome c reductases, cytochrome oxidase and acid phosphatase.大鼠腹侧前列腺的组织分级分离研究：核酸、琥珀酸氧化系统、细胞色素c还原酶、细胞色素氧化酶和酸性磷酸酶的亚细胞分布
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Effects of growth hormone and tri-iodothyronine on amino acid incorporation by microsomal subfractions from rat liver.生长激素和三碘甲状腺原氨酸对大鼠肝脏微粒体亚组分氨基酸掺入的影响。
Eur J Biochem. 1967 Oct;2(3):366-74. doi: 10.1111/j.1432-1033.1967.tb00147.x.
10
The effects of diethylstilboestrol and castration on the nucleic acid and protein metabolism of rat prostate gland.己烯雌酚和去势对大鼠前列腺核酸及蛋白质代谢的影响。
Biochem J. 1967 Sep;104(3):1075-81. doi: 10.1042/bj1041075.
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