关于睾酮对雄激素依赖性组织中蛋白质合成刺激作用的进一步研究。
Further studies on the stimulation of protein synthesis in androgen-dependent tissues by testosterone.
作者信息
Mainwaring W I, Wilce P A
出版信息
Biochem J. 1972 Nov;130(1):189-97. doi: 10.1042/bj1300189.
Abstract
- By using centrifugation through a discontinuous sucrose gradient, four microsomal fractions are obtained from the prostate gland. 2. Administration of androgens to castrated rats stimulates protein synthesis in all fractions, particularly in the heavy rough fraction. 3. Androgens also increase the content of protein, RNA and phospholipid in the heavy rough fraction. 4. Time-course experiments in vivo show that androgens induce a rapid increase in the synthesis of ribosomal precursor RNA preceding the synthesis of new microsomal fraction and the increase in protein synthesis.
摘要
- 通过在不连续蔗糖梯度中进行离心，可从前列腺获得四个微粒体组分。2. 给去势大鼠注射雄激素会刺激所有组分中的蛋白质合成，尤其是在重质粗面组分中。3. 雄激素还会增加重质粗面组分中蛋白质、RNA和磷脂的含量。4. 体内的时间进程实验表明，雄激素会在新微粒体组分合成和蛋白质合成增加之前，诱导核糖体前体RNA合成迅速增加。
相似文献
1
Further studies on the stimulation of protein synthesis in androgen-dependent tissues by testosterone.
Biochem J. 1972 Nov;130(1):189-97. doi: 10.1042/bj1300189.
2
The control of the form and function of the ribosomes in androgen-dependent tissues by testosterone.
Biochem J. 1973 Jul;134(3):795-805. doi: 10.1042/bj1340795.
3
Studies on the form and synthesis of messenger ribonucleic acid in the rat ventral prostate gland, including its tissue-specific stimulation by androgens.
Biochem J. 1974 Mar;137(3):513-24. doi: 10.1042/bj1370513.
4
Co-ordination between membrane phospholipid synthesis and accelerated biosynthesis of cytoplasmic ribonucleic acid and protein.
Biochem J. 1970 Feb;116(4):617-30. doi: 10.1042/bj1160617.
5
Effect of inhibitors of RNA and protein synthesis on the prostatic response to testosterone.
Biochim Biophys Acta. 1972 Sep 14;277(3):595-605. doi: 10.1016/0005-2787(72)90104-9.
6
Androgenic regulation of nucleic acid and protein synthesis in the hamster flank organ and other tissues.
Endocrinology. 1971 Sep;89(3):904-9. doi: 10.1210/endo-89-3-904.
7
The formation, distribution and function of ribosomes and microsomal membranes during induced amphibian metamorphosis.
Biochem J. 1967 Nov;105(2):783-801. doi: 10.1042/bj1050783.
8
5 -dihydrotestosterone and the synthesis of RNA in the rat ventral prostate in vitro.
Acta Endocrinol (Copenh). 1971 Nov;68(3):567-75. doi: 10.1530/acta.0.0680567.
9
[In vivo effects of androgens on nucleic acid metabolism, II. The effect of testosterone on the incorporation of (3H)uridine into the RNA of the prostate and seminal vesicles of young rats (author's transl)].
Hoppe Seylers Z Physiol Chem. 1973 Sep;354(9):1141-5.
10
Incorporation of amino acids into proteins catalyzed by prostate nuclei.
Exp Cell Res. 1971 Jun;66(2):273-82. doi: 10.1016/0014-4827(71)90678-1.
引用本文的文献
1
Prostate gland: structure, functions and regulation.
Int Urol Nephrol. 1995;27(3):231-43. doi: 10.1007/BF02564756.
2
The control of the form and function of the ribosomes in androgen-dependent tissues by testosterone.
Biochem J. 1973 Jul;134(3):795-805. doi: 10.1042/bj1340795.
3
Specific changes in the messenger ribonucleic acid content of the rat ventral prostate gland after androgenic stimulation. Evidence from the synthesis of aldolase messenger ribonucleic acid.
Biochem J. 1974 Nov;144(2):413-26. doi: 10.1042/bj1440413.
4
Effect of duration of the period after castration on the response of the rat ventral prostate to androgens.
Biochem J. 1974 Aug;142(2):429-31. doi: 10.1042/bj1420429.
5
Studies on the form and synthesis of messenger ribonucleic acid in the rat ventral prostate gland, including its tissue-specific stimulation by androgens.
Biochem J. 1974 Mar;137(3):513-24. doi: 10.1042/bj1370513.
6
The use of deoxyribonucleic acid-cellulose chromatography and isoelectric focusing for the characterization and partial purification of steroid-receptor complexes.
Biochem J. 1973 May;134(1):113-27. doi: 10.1042/bj1340113.
7
Androgen-dependent synthesis of basic secretory proteins by the rat seminal vesicle.
Biochem J. 1976 Aug 15;158(2):271-82. doi: 10.1042/bj1580271.
8
The androgenic regulation of prostate proteins with a high affinity for deoxyribonucleic acid. Evidence for a prostate deoxyribonucleic acid-unwinding protein.
Biochem J. 1976 May 15;156(2):253-64. doi: 10.1042/bj1560253.
9
Nuclear components responsible for the retention of steroid--receptor complexes, especially from the standpoint of the specifcity of hormonal responses.
Biochem J. 1976 Apr 15;156(1):129-41. doi: 10.1042/bj1560129.
本文引用的文献
1
Regulation of polyribosome formation and protein synthesis in the uterus. Effect of ovariectomy and administration of oestradiol-17beta on the amino acid-incorporation activity in vitro and the cytoplasmic concentration in vivo of polyribosomal preparation.
Biochem J. 1967 Dec;105(3):1101-9. doi: 10.1042/bj1051101.
2
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75.
3
GROWTH HORMONE CONTROL OF BIOSYNTHESIS OF PROTEIN AND RIBONUCLEIC ACID.
Recent Prog Horm Res. 1965;21:205-40.
4
ENTRANCE OF NEWLY FORMED MESSENGER RNA AND RIBOSOMES INTO HELA CELL CYTOPLASM.
J Mol Biol. 1965 Feb;11:187-201. doi: 10.1016/s0022-2836(65)80050-x.
5
TESTICULAR HORMONES AND THE SYNTHESIS OF RIBONUCLEIC ACIDS AND PROTEINS IN THE PROSTATE GLAND.
Recent Prog Horm Res. 1964;20:247-301.
6
An effect of testosterone on amino acid incorporation by prostatic ribonucleoprotein particles.
Proc Natl Acad Sci U S A. 1962 Nov 15;48(11):1956-64. doi: 10.1073/pnas.48.11.1956.
7
A tissue fractionation study of rat ventral prostate: subcellular distribution of nucleic acids, succinate oxidizing systems, cytochrome c reductases, cytochrome oxidase and acid phosphatase.
Biochim Biophys Acta. 1961 Nov 25;54:42-51. doi: 10.1016/0006-3002(61)90935-0.
8
Ribonuclease. V. Studies on the properties and distribution of ribonuclease inhibitor in the rat.
Biochim Biophys Acta. 1956 Jul;21(1):34-43. doi: 10.1016/0006-3002(56)90091-9.
9
Effects of growth hormone and tri-iodothyronine on amino acid incorporation by microsomal subfractions from rat liver.
Eur J Biochem. 1967 Oct;2(3):366-74. doi: 10.1111/j.1432-1033.1967.tb00147.x.
10
The effects of diethylstilboestrol and castration on the nucleic acid and protein metabolism of rat prostate gland.
Biochem J. 1967 Sep;104(3):1075-81. doi: 10.1042/bj1041075.
Zotero 插件