• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

己烯雌酚和去势对大鼠前列腺核酸及蛋白质代谢的影响。

The effects of diethylstilboestrol and castration on the nucleic acid and protein metabolism of rat prostate gland.

作者信息

Mangan F R, Neal G E, Williams D C

出版信息

Biochem J. 1967 Sep;104(3):1075-81. doi: 10.1042/bj1041075.

DOI:10.1042/bj1041075
PMID:6049858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1271254/
Abstract
  1. Implantation of diethylstilboestrol pellets into adult male rats brings about similar biochemical changes in the nucleic acid and protein metabolism to castration. 2. The avidity of the prostate for labelled diethylstilboestrol was greater than that of the other organs examined. 3. Uptake of labelled diethylstilboestrol and testosterone into the nuclei of the rat prostate is greater in castrated rats than in controls. 4. Diethylstilboestrol appeared to be associated with the protein and not with the DNA fraction of the nucleus.
摘要
  1. 将己烯雌酚丸植入成年雄性大鼠体内会引起核酸和蛋白质代谢方面与去势相似的生化变化。2. 前列腺对标记己烯雌酚的亲和力大于所检查的其他器官。3. 去势大鼠前列腺细胞核对标记己烯雌酚和睾酮的摄取量高于对照组。4. 己烯雌酚似乎与细胞核的蛋白质部分相关，而非与DNA部分相关。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/1271254/6fd4838471da/biochemj00739-0385-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/1271254/eca8ea892e8c/biochemj00739-0385-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/1271254/7fd8c3a6097e/biochemj00739-0385-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/1271254/6fd4838471da/biochemj00739-0385-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/1271254/eca8ea892e8c/biochemj00739-0385-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/1271254/7fd8c3a6097e/biochemj00739-0385-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/666f/1271254/6fd4838471da/biochemj00739-0385-c.jpg

相似文献

1
The effects of diethylstilboestrol and castration on the nucleic acid and protein metabolism of rat prostate gland.己烯雌酚和去势对大鼠前列腺核酸及蛋白质代谢的影响。
Biochem J. 1967 Sep;104(3):1075-81. doi: 10.1042/bj1041075.
2
Testosterone action in the rat ventral prostate. The effects of diethylstilboestrol and cyproterone acetate on the metabolism of ( 3 H)testosterone and the retention of labelled metabolites by rat ventral prostate in vivo and in vitro.睾酮在大鼠前列腺腹叶中的作用。己烯雌酚和醋酸环丙孕酮对（3H）睾酮代谢及大鼠前列腺腹叶在体内和体外对标记代谢物的潴留的影响。
Biochem J. 1971 Nov;125(1):81-91. doi: 10.1042/bj1250081.
3
Polyamines and testosterone on nucleic acid biosynthesis in the prostate gland of the rat.多胺与睾酮对大鼠前列腺核酸生物合成的影响
Ital J Biochem. 1971 Jan-Apr;20(1):6-15.
4
Subcellular distribution of testosterone in rat prostate and its possible relationship to nuclear ribonucleic acid synthesis.
Arch Biochem Biophys. 1968 Mar 20;124(1):27-40. doi: 10.1016/0003-9861(68)90300-7.
5
Effects of androgen in vivo on some properties of isolated rat ventral prostate nuclei.
Exp Cell Res. 1970 Aug;61(2):371-8. doi: 10.1016/0014-4827(70)90460-x.
6
Further studies on the stimulation of protein synthesis in androgen-dependent tissues by testosterone.关于睾酮对雄激素依赖性组织中蛋白质合成刺激作用的进一步研究。
Biochem J. 1972 Nov;130(1):189-97. doi: 10.1042/bj1300189.
7
Effect of an anti-androgenic steroid on the testosterone-stimulated activity of aggregate polymerase in the prostate nuclei of rats.一种抗雄激素类固醇对大鼠前列腺细胞核中睾酮刺激的聚合酶活性的影响。
Hoppe Seylers Z Physiol Chem. 1967 Aug;348(8):1085-6.
8
Effects of inhibitors of nucleic acids and protein biosynthesis on the rate of 5 alpha-reduction of testosterone, the activity of DNA polymerase and nucleic acid contents of testosterone-stimulated prostate of rats.
Endocrinol Jpn. 1970 Apr;17(2):175-9. doi: 10.1507/endocrj1954.17.175.
9
Effects of dihydrotestosterone on the synthesis of nucleic acid and ATP in prostatic nuclei.双氢睾酮对前列腺细胞核中核酸及三磷酸腺苷合成的影响。
Biochem Biophys Res Commun. 1969 Dec 4;37(6):976-81. doi: 10.1016/0006-291x(69)90227-7.
10
Binding of androgens to a nuclear-envelope fraction from the rat ventral prostate.雄激素与大鼠腹侧前列腺核膜组分的结合。
Biochem J. 1980 Mar 15;186(3):641-7. doi: 10.1042/bj1860641.

引用本文的文献

1
Relationship of oestrogen receptor alpha gene polymorphisms with risk for benign prostatic hyperplasia and prostate cancer in Chinese men.中国男性雌激素受体α基因多态性与良性前列腺增生症和前列腺癌风险的关系。
Medicine (Baltimore). 2017 Mar;96(13):e6473. doi: 10.1097/MD.0000000000006473.
2
Signaling through estrogen receptors modulates telomerase activity in human prostate cancer.通过雌激素受体发出的信号调节人类前列腺癌中的端粒酶活性。
J Clin Invest. 2002 Jul;110(2):219-27. doi: 10.1172/JCI15552.
3
Changes in the ribonucleic acid metabolism of aging mouse tissues with particular reference to the prostate gland.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
POSSIBLE SYNTHESIS OF POLYRIBONUCLEOTIDES OF KNOWN BASE-TRIPLET SEQUENCES.已知碱基三联体序列的多核糖核苷酸的可能合成
Nature. 1965 Apr 3;206:93. doi: 10.1038/206093b0.
3
TESTICULAR HORMONES AND THE SYNTHESIS OF RIBONUCLEIC ACIDS AND PROTEINS IN THE PROSTATE GLAND.睾丸激素与前列腺中核糖核酸和蛋白质的合成
衰老小鼠组织核糖核酸代谢的变化，特别涉及前列腺。
Biochem J. 1968 Nov;110(1):79-86. doi: 10.1042/bj1100079.
4
The inhibition of deoxyribonucleic acid nucleotidyltransferase by stilboestrol derivatives.己烯雌酚衍生物对脱氧核糖核酸核苷酸转移酶的抑制作用。
Biochem J. 1968 Aug;108(5):749-53. doi: 10.1042/bj1080749.
5
Studies on steroid fever. II. Pyrogenic and anti-pyrogenic activity in vitro of some endogenous steroids of man.类固醇热的研究。II. 人体某些内源性类固醇的体外致热和抗热活性
J Clin Invest. 1970 Dec;49(12):2418-26. doi: 10.1172/JCI106461.
6
The control of the form and function of the ribosomes in androgen-dependent tissues by testosterone.睾酮对雄激素依赖组织中核糖体的形态和功能的控制。
Biochem J. 1973 Jul;134(3):795-805. doi: 10.1042/bj1340795.
7
Hormonal effects in vitro on prostatic ribonucleic acid polymerase.激素对前列腺核糖核酸聚合酶的体外作用。
Biochem J. 1972 Oct;129(5):1167-9. doi: 10.1042/bj1291167.
8
Further studies on the stimulation of protein synthesis in androgen-dependent tissues by testosterone.关于睾酮对雄激素依赖性组织中蛋白质合成刺激作用的进一步研究。
Biochem J. 1972 Nov;130(1):189-97. doi: 10.1042/bj1300189.
9
Androgen-dependent synthesis of basic secretory proteins by the rat seminal vesicle.大鼠精囊雄激素依赖性碱性分泌蛋白的合成。
Biochem J. 1976 Aug 15;158(2):271-82. doi: 10.1042/bj1580271.
Recent Prog Horm Res. 1964;20:247-301.
4
INFLUENCE OF TESTOSTERONE ON TEMPLATE ACTIVITY OF PROSTATIC RIBONUCLEIC ACIDS.睾酮对前列腺核糖核酸模板活性的影响
J Biol Chem. 1965 Mar;240:1236-43.
5
A STRUCTURAL STUDY OF RAT LIVER RIBOSOMES.大鼠肝脏核糖体的结构研究。
J Cell Biol. 1965 Apr;25(1):9-22. doi: 10.1083/jcb.25.1.9.
6
DENSITY GRADIENT CENTRIFUGATION IN ANGLE-HEAD ROTORS.
Anal Biochem. 1964 Dec;9:477-82. doi: 10.1016/0003-2697(64)90209-x.
7
EARLY ESTROGEN EFFECTS ON THE ACTIVITY OF UTERINE RIBONUCLEIC ACID POLYMERASE.雌激素对子宫核糖核酸聚合酶活性的早期影响。
J Biol Chem. 1964 Mar;239:889-92.
8
DETERMINATION OF THE CODING RATIO BASED ON MOLECULAR WEIGHT OF MESSENGER RIBONUCLEIC ACID ASSOCIATED WITH ERGOSOMES OF DIFFERENT AGGREGATE SIZE.基于与不同聚集体大小的麦角体相关的信使核糖核酸分子量确定编码率
Nature. 1964 Jan 18;201:264-70. doi: 10.1038/201264a0.
9
GROWTH PATTERN OF THE MOUSE PROSTATE GLAND IN ORGAN CULTURE AND ITS RESPONSE TO SEX HORMONES, VITAMIN A, AND 3-METHYLCHOLANTHRENE.小鼠前列腺在器官培养中的生长模式及其对性激素、维生素A和3-甲基胆蒽的反应
Natl Cancer Inst Monogr. 1963 Oct;12:381-403.
10
INFLUENCE OF TESTOSTERONE AND POLYURIDYLIC ACID ON THE INCORPORATION OF PHENYLALANINE INTO PEPTIDE LINKAGE BY PROSTATIC RIBOSOMES.睾酮与聚尿苷酸对前列腺核糖体将苯丙氨酸掺入肽键的影响。
Nature. 1963 Aug 24;199:808-9. doi: 10.1038/199808a0.