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1
Experimental oral immunization with L-forms of Vibrio cholerae.霍乱弧菌L型的实验性口服免疫
Infect Immun. 1972 Jan;5(1):31-4. doi: 10.1128/iai.5.1.31-34.1972.
2
Oral immunization with L-forms of Vibrio cholerae in human volunteers.用霍乱弧菌L型对人类志愿者进行口服免疫。
Infect Immun. 1972 Jul;6(1):17-20. doi: 10.1128/iai.6.1.17-20.1972.
3
Cell-mediated immunity after oral immunization with ribonucleic acid-protein fractions of Vibrio cholerae L-form lysates.用霍乱弧菌L型裂解物的核糖核酸-蛋白质组分经口服免疫后的细胞介导免疫。
Infect Immun. 1977 May;16(2):527-30. doi: 10.1128/iai.16.2.527-530.1977.
4
Agglutinin and vibriocidal responses of L forms of Vibrio cholerae and El tor.霍乱弧菌和埃尔托弧菌L型的凝集素及杀弧菌反应
Indian J Med Res. 1971 Jun;59(6):866-72.
5
[Intestinal antibodies against lipopolysaccharide antigens of NAG vibrio in rabbits immunized by the oral route (author's transl)].经口服途径免疫的兔体内针对NAG弧菌脂多糖抗原的肠道抗体（作者译）
Cesk Epidemiol Mikrobiol Imunol. 1979 Jul;28(4):193-200.
6
Detection and enumeration of immunocytes producing different classes of vibriolysins after primary and secondary immunization with cholera vaccine.霍乱疫苗初次和二次免疫后产生不同类弧菌溶素的免疫细胞的检测与计数。
J Immunol. 1974 Dec;113(6):1815-22.
7
Response of man to infection with Vibrio cholerae. II. Protection from illness afforded by previous disease and vaccine.人类对霍乱弧菌感染的反应。II. 既往疾病和疫苗提供的疾病防护。
J Infect Dis. 1974 Oct;130(4):325-33. doi: 10.1093/infdis/130.4.325.
8
Cell-mediated immunity to Vibrio cholerae with ribonucleic acid-protein fractions of V. cholerae L-form lysates.霍乱弧菌L型裂解物的核糖核酸-蛋白质组分介导的对霍乱弧菌的细胞免疫。
Infect Immun. 1976 Aug;14(2):363-7. doi: 10.1128/iai.14.2.363-367.1976.
9
Source and protective function of coproantibodies in intestinal disease.粪便抗体在肠道疾病中的来源及保护作用
Am J Clin Nutr. 1972 Dec;25(12):1357-63. doi: 10.1093/ajcn/25.12.1357.
10
Construction of non-toxic Escherichia coli and Vibrio cholerae strains expressing high and immunogenic levels of enterotoxigenic E. coli colonization factor I fimbriae.构建表达高免疫原性水平的产肠毒素大肠杆菌定植因子I菌毛的无毒大肠杆菌和霍乱弧菌菌株。
Vaccine. 2008 Feb 6;26(6):743-52. doi: 10.1016/j.vaccine.2007.12.009. Epub 2007 Dec 26.

引用本文的文献

1
Comparison of quantitative and qualitative antibody-producing cell responses to lipopolysaccharide in cell walls of the bacterial form and in membranes of the protoplast L-form of Proteus mirabilis.奇异变形杆菌细菌型细胞壁和原生质体L型细胞膜中脂多糖诱导的定量和定性抗体产生细胞反应的比较
Infect Immun. 1980 Nov;30(2):349-52. doi: 10.1128/iai.30.2.349-352.1980.
2
Oral immunization with L-forms of Vibrio cholerae in human volunteers.用霍乱弧菌L型对人类志愿者进行口服免疫。
Infect Immun. 1972 Jul;6(1):17-20. doi: 10.1128/iai.6.1.17-20.1972.
3
Cell-mediated immunity to Vibrio cholerae with ribonucleic acid-protein fractions of V. cholerae L-form lysates.霍乱弧菌L型裂解物的核糖核酸-蛋白质组分介导的对霍乱弧菌的细胞免疫。
Infect Immun. 1976 Aug;14(2):363-7. doi: 10.1128/iai.14.2.363-367.1976.
4
Cell-mediated immunity after oral immunization with ribonucleic acid-protein fractions of Vibrio cholerae L-form lysates.用霍乱弧菌L型裂解物的核糖核酸-蛋白质组分经口服免疫后的细胞介导免疫。
Infect Immun. 1977 May;16(2):527-30. doi: 10.1128/iai.16.2.527-530.1977.
5
Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells.霍乱弧菌和产肠毒素大肠杆菌及其外毒素对真核细胞的病理生理作用。
Microbiol Rev. 1978 Sep;42(3):592-613. doi: 10.1128/mr.42.3.592-613.1978.

本文引用的文献

1
Quantitative studies of the relationship between fecal and serum antibody.粪便与血清抗体之间关系的定量研究。
J Immunol. 1950 Jul;65(1):93-103.
2
The importance of antibody in the prevention of experimental cholera in rabbits.抗体在预防家兔实验性霍乱中的重要性。
Br J Exp Pathol. 1960 Feb;41(1):24-30.
3
ORAL IMMUNIZATION AND PRODUCTION OF COPROANTIBODY IN HUMAN VOLUNTEERS.人体志愿者的口服免疫及粪抗体产生
J Immunol. 1963 Dec;91:724-9.
4
Coproantibody and bacterial antagonism as protective factors in experimental enteric cholera.粪便抗体和细菌拮抗作用作为实验性肠道霍乱中的保护因素。
J Exp Med. 1956 Sep 1;104(3):419-26. doi: 10.1084/jem.104.3.419.
5
Quantitative studies of the virus-host relationship in chimpanzees after inapparent infection with Coxsackie viruses. I. The virus carrier state and the development of neutralizing antibodies.柯萨奇病毒隐性感染后黑猩猩病毒-宿主关系的定量研究。I. 病毒携带状态及中和抗体的产生
J Exp Med. 1953 Mar;97(3):367-400. doi: 10.1084/jem.97.3.367.
6
Production of antitoxic immunity by live oral cholera vaccine.口服霍乱活疫苗产生抗毒素免疫力。
J Bacteriol. 1968 Jan;95(1):255-6. doi: 10.1128/jb.95.1.255-256.1968.
7
Live oral cholera vaccine: report of a trial on human volunteer subjects.口服霍乱活疫苗：人体志愿者试验报告。
Bull World Health Organ. 1969 Apr;40(4):503-11.
8
Further studies on the development of a live oral cholera vaccine.口服霍乱活疫苗研发的进一步研究
J Hyg (Lond). 1968 Jun;66(2):307-18. doi: 10.1017/s0022172400041164.
9
Agglutinin and vibriocidal responses of L forms of Vibrio cholerae and El tor.霍乱弧菌和埃尔托弧菌L型的凝集素及杀弧菌反应
Indian J Med Res. 1971 Jun;59(6):866-72.
10
Vibriocidal activity, immune globulin producing cells and immune globulin levels in Theropithecus gelada after administration of a vibrio cholerae antigen.给予霍乱弧菌抗原后狮尾狒的杀弧菌活性、免疫球蛋白产生细胞及免疫球蛋白水平
Immunology. 1968 Mar;14(3):319-24.

霍乱弧菌L型的实验性口服免疫

Experimental oral immunization with L-forms of Vibrio cholerae.

作者信息

Agarwal S C, Ganguly N K

出版信息

Infect Immun. 1972 Jan;5(1):31-4. doi: 10.1128/iai.5.1.31-34.1972.

DOI:10.1128/iai.5.1.31-34.1972
PMID:4656355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422316/
Abstract

It has been found that oral administration of lysates of L-forms of Vibrio cholerae are antigenic and capable of eliciting an early and high coproantibody response. The L-forms of V. cholerae did not produce any booster effect. Coproantibody rise persists to significant levels even six weeks after oral immunization. L-form lysates of V. cholerae also produce a considerable rise of circulating antibodies and these persist in significantly high titers up to six weeks.

摘要

已发现口服霍乱弧菌L型菌的裂解物具有抗原性，能够引发早期且强烈的粪便抗体反应。霍乱弧菌L型菌未产生任何加强效应。即使在口服免疫六周后，粪便抗体水平仍持续显著升高。霍乱弧菌L型菌裂解物还会使循环抗体显著升高，且这些抗体在高达六周的时间内一直保持在显著的高滴度水平。