• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Oral immunization with L-forms of Vibrio cholerae in human volunteers.用霍乱弧菌L型对人类志愿者进行口服免疫。
Infect Immun. 1972 Jul;6(1):17-20. doi: 10.1128/iai.6.1.17-20.1972.
2
Experimental oral immunization with L-forms of Vibrio cholerae.霍乱弧菌L型的实验性口服免疫
Infect Immun. 1972 Jan;5(1):31-4. doi: 10.1128/iai.5.1.31-34.1972.
3
Agglutinin and vibriocidal responses of L forms of Vibrio cholerae and El tor.霍乱弧菌和埃尔托弧菌L型的凝集素及杀弧菌反应
Indian J Med Res. 1971 Jun;59(6):866-72.
4
Cell-mediated immunity after oral immunization with ribonucleic acid-protein fractions of Vibrio cholerae L-form lysates.用霍乱弧菌L型裂解物的核糖核酸-蛋白质组分经口服免疫后的细胞介导免疫。
Infect Immun. 1977 May;16(2):527-30. doi: 10.1128/iai.16.2.527-530.1977.
5
Local and systemic immune responses to combined vibrio cholerae CVD103-HgR and salmonella typhi ty21a live oral vaccines after primary immunization and reimmunization.霍乱弧菌CVD103-HgR与伤寒沙门氏菌Ty21a联合口服活疫苗初次免疫和再次免疫后的局部和全身免疫反应
Vaccine. 2000 Jul 1;18(26):3031-9. doi: 10.1016/s0264-410x(00)00101-8.
6
The vaccine candidate Vibrio cholerae 638 is protective against cholera in healthy volunteers.候选疫苗霍乱弧菌638对健康志愿者具有霍乱预防作用。
Infect Immun. 2005 May;73(5):3018-24. doi: 10.1128/IAI.73.5.3018-3024.2005.
7
Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other mucosal and systemic responses.在孟加拉国受试者口服灭活二价霍乱弧菌O1/O139全细胞霍乱疫苗免疫后，在其黏膜表面检测到强大的肠道相关疫苗特异性抗体分泌细胞反应：与其他黏膜和全身反应的比较。
Vaccine. 2009 Feb 25;27(9):1386-92. doi: 10.1016/j.vaccine.2008.12.041. Epub 2009 Jan 13.
8
Murine antibody responses following systemic or mucosal immunization with viable or inactivated Vibrio cholerae.用活的或灭活的霍乱弧菌进行全身或黏膜免疫后小鼠的抗体反应。
Vaccine. 2008 Dec 9;26(52):6784-90. doi: 10.1016/j.vaccine.2008.10.011. Epub 2008 Oct 23.
9
Protective antigens from El Tor vibrios. 1. The preparation and properties of a purified protective antigen from an El Tor vibrio (Ogawa subtype).埃尔托弧菌的保护性抗原。1. 一株埃尔托弧菌（小川亚型）纯化保护性抗原的制备及特性
Bull World Health Organ. 1965;32(6):809-21.
10
[Study of the immunological effectiveness of the enteral vaccination of volunteers with detergent Sonne dysentery monovaccine].
Zh Mikrobiol Epidemiol Immunobiol. 1977 Aug(8):26-31.

引用本文的文献

1
Vaccines and cell-mediated immunity.疫苗与细胞介导免疫
Bacteriol Rev. 1974 Dec;38(4):371-402. doi: 10.1128/br.38.4.371-402.1974.
2
Cell-mediated immunity to Vibrio cholerae with ribonucleic acid-protein fractions of V. cholerae L-form lysates.霍乱弧菌L型裂解物的核糖核酸-蛋白质组分介导的对霍乱弧菌的细胞免疫。
Infect Immun. 1976 Aug;14(2):363-7. doi: 10.1128/iai.14.2.363-367.1976.
3
Cell-mediated immunity after oral immunization with ribonucleic acid-protein fractions of Vibrio cholerae L-form lysates.用霍乱弧菌L型裂解物的核糖核酸-蛋白质组分经口服免疫后的细胞介导免疫。
Infect Immun. 1977 May;16(2):527-30. doi: 10.1128/iai.16.2.527-530.1977.
4
Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells.霍乱弧菌和产肠毒素大肠杆菌及其外毒素对真核细胞的病理生理作用。
Microbiol Rev. 1978 Sep;42(3):592-613. doi: 10.1128/mr.42.3.592-613.1978.

本文引用的文献

1
A new test for the identification of roughness in Vibrio cholerae.
Indian J Med Res. 1951 Jul;39(3):417-21.
2
ORAL IMMUNIZATION AND PRODUCTION OF COPROANTIBODY IN HUMAN VOLUNTEERS.人体志愿者的口服免疫及粪抗体产生
J Immunol. 1963 Dec;91:724-9.
3
Live oral cholera vaccine: report of a trial on human volunteer subjects.口服霍乱活疫苗：人体志愿者试验报告。
Bull World Health Organ. 1969 Apr;40(4):503-11.
4
Agglutinin and vibriocidal responses of L forms of Vibrio cholerae and El tor.霍乱弧菌和埃尔托弧菌L型的凝集素及杀弧菌反应
Indian J Med Res. 1971 Jun;59(6):866-72.
5
Experimental oral immunization with L-forms of Vibrio cholerae.霍乱弧菌L型的实验性口服免疫
Infect Immun. 1972 Jan;5(1):31-4. doi: 10.1128/iai.5.1.31-34.1972.

用霍乱弧菌L型对人类志愿者进行口服免疫。

Oral immunization with L-forms of Vibrio cholerae in human volunteers.

作者信息

Agarwal S C, Ganguly N K

出版信息

Infect Immun. 1972 Jul;6(1):17-20. doi: 10.1128/iai.6.1.17-20.1972.

DOI:10.1128/iai.6.1.17-20.1972
PMID:4634456
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422483/
Abstract

Oral administration of heat-inactivated lysates of Vibrio cholerae Ogawa L-forms elicited significantly high coproantibody, serum indirect hemagglutinating antibody, and vibriocidal antibody responses in human volunteers, against both homologous and heterologous subtypes of V. cholerae and V. El Tor. Five oral biweekly doses produced an adequate antibody response which persisted for at least 6 weeks after immunization. No untoward side effects were seen.

摘要

对人体志愿者口服经热灭活的霍乱弧菌小川型L型裂解物后，针对霍乱弧菌和埃尔托弧菌的同源及异源亚型，均可引发显著高水平的粪便抗体、血清间接血凝抗体及杀弧菌抗体反应。每两周口服一剂，连续五剂后可产生足够的抗体反应，且该反应在免疫后至少持续6周。未观察到不良副作用。