霍乱弧菌L型裂解物的核糖核酸-蛋白质组分介导的对霍乱弧菌的细胞免疫。
Cell-mediated immunity to Vibrio cholerae with ribonucleic acid-protein fractions of V. cholerae L-form lysates.
作者信息
Agarwal S C, Sundararaj T
出版信息
Infect Immun. 1976 Aug;14(2):363-7. doi: 10.1128/iai.14.2.363-367.1976.
Abstract
Different L-form lysate vaccines of Vibrio cholerae serotypes Ogawa and Inaba and their combination along with ethyl alcohol-precipitated ribonucleic acid (E-RNA) and phenol-extracted RNA (P-RNA) fractions of V. cholerae Ogawa lysates were tested for production of cell-mediated immunity. Both E-RNA and P-RNA fractions induced an increase in leukocyte migration inhibition, macrophage migration inhibition, and macrophage aggregation. They also induced delayed hypersensitivity in rabbits. More consistent results were obtained with the P-RNA fraction.
摘要
对霍乱弧菌小川型和稻叶型不同的L型溶菌疫苗及其组合，以及小川型霍乱弧菌溶菌产物的乙醇沉淀核糖核酸（E-RNA）和酚提取RNA（P-RNA）组分进行了细胞介导免疫产生的测试。E-RNA和P-RNA组分均诱导白细胞迁移抑制、巨噬细胞迁移抑制和巨噬细胞聚集增加。它们还在兔中诱导了迟发型超敏反应。P-RNA组分获得了更一致的结果。
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