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蟑螂血淋巴中的特异性血凝素和补体调节剂。

Specific hemagglutinin and a modulator of complement in cockroach hemolymph.

作者信息

Anderson R S, Day N K, Good R A

出版信息

Infect Immun. 1972 Jan;5(1):55-9. doi: 10.1128/iai.5.1.55-59.1972.

Abstract

Natural hemagglutinin activity against vertebrate erythrocytes is present in the hemolymph of the cockroach Blabarus craniifer. The hemagglutinin titer against rabbit erythrocytes is high, whereas sheep and horse red cells agglutinate weakly. Hemagglutinin activity was depressed by the complement inhibitor, cobra venom factor. Cockroach hemagglutinin is heat-labile; all activity is destroyed by heating at 56 C for 1 hr. A humoral factor similar to the complement component 3 proactivator is also present in cockroach hemolymph. The formation of the cobra venom factor-hemolymph "complex" is dependent on the presence of divalent cations and will not proceed at 56 C. The hemolytic intermediate formed after treatment of cockroach hemolymph with cobra venom factor was active in the presence of serum treated with ethylenediaminetetraacetic acid to inactivate the early complement components.

摘要

在美洲大蠊的血淋巴中存在针对脊椎动物红细胞的天然血凝素活性。针对兔红细胞的血凝素效价很高,而绵羊和马的红细胞凝集较弱。补体抑制剂眼镜蛇毒因子可降低血凝素活性。蟑螂血凝素对热不稳定;在56℃加热1小时可破坏所有活性。蟑螂血淋巴中还存在一种类似于补体成分3前活化剂的体液因子。眼镜蛇毒因子 - 血淋巴“复合物”的形成依赖于二价阳离子的存在,且在56℃时不会发生。用眼镜蛇毒因子处理蟑螂血淋巴后形成的溶血中间体在用乙二胺四乙酸处理以灭活早期补体成分的血清存在下具有活性。

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Simple methods of rabbit hemolytic complement component assays.兔溶血补体成分测定的简单方法。
Int Arch Allergy Appl Immunol. 1974;46(4):539-51. doi: 10.1159/000231156.

本文引用的文献

1
Hemagglutinins in caterpillar bloods.毛虫血液中的血凝素。
Science. 1952 Feb 8;115(2980):150-1. doi: 10.1126/science.115.2980.150.
5
Immune response of locusts to venom of the scorpion.蝗虫对蝎毒的免疫反应。
J Invertebr Pathol. 1965 Jun;7(2):192-8. doi: 10.1016/0022-2011(65)90037-6.
8
Significance of complement to the mechanism of action of endotoxin.补体在内毒素作用机制中的意义。
Curr Top Microbiol Immunol. 1969;50:37-77. doi: 10.1007/978-3-642-46169-9_2.
10
Serological responses of insects.
Fed Proc. 1967 Nov-Dec;26(6):1675-9.

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