The effect of high glucose concentration on the proliferation and the synthesis of lipids in endothelial cells in culture.

Influence of glucose concentration on growth and lipid synthesis was investigated in human endothelial cells in culture. The biosynthesis of lipids from acetate and glucose was present in endothelial cells, but a high glucose level in the culture medium failed to modify lipid synthesis. Neosynthesis in the lipidic fraction in the medium is higher when precursor is acetate compared to glucose.