Koenig H M, Lightsey A L, Nelson D P, Diamond L K
Blood. 1979 Sep;54(3):742-6.
Serum and IgG from four children with transient erythroblastopenia of childhood (TEC) was tested to see what effect it would have on development of erythroid colonies from bone marrow mononuclear cells. Serum and IgG specimens obtained at the time of diagnosis uniformly suppressed erythroid colony development from CFU-E. Washed bone marrow mononuclear cells from a child with TEC failed to grow in the presence of his own serum, but grew normally in the presence of isologous serum. Serum specimens obtained from patients after recovery from TEC had no effect on erythroid colony development. The anemia of TEC appears to be due to transient immune suppression of erythroid colony development.
对4例儿童暂时性红细胞生成减少症（TEC）患儿的血清和IgG进行检测，以观察其对骨髓单个核细胞红系集落发育的影响。诊断时获取的血清和IgG标本均能抑制CFU-E的红系集落发育。1例TEC患儿的洗涤骨髓单个核细胞在其自身血清存在的情况下无法生长，但在同种血清存在时生长正常。TEC患儿恢复后获取的血清标本对红系集落发育无影响。TEC的贫血似乎是由于红系集落发育受到暂时性免疫抑制所致。
