Freedman M H
Am J Dis Child. 1983 May;137(5):458-60. doi: 10.1001/archpedi.1983.02140310040011.
An anemia of childhood with reticulocytopenia and marrow RBC aplasia was found to be due to immune-mediated erythropoietic suppression. In vitro assays of marrow and peripheral blood erythroid progenitors indicated normal cell numbers that markedly declined when autologous serum or IgM was added to the cultures, but remained unchanged with autologous IgG or with autologous serum depleted of IgM. In contrast to "transient" erythroblastopenia of childhood, this anemia was recurrent, lasted longer, and seemed to be prednisone responsive.
一种伴有网织红细胞减少和骨髓红细胞再生障碍的儿童贫血被发现是由免疫介导的红细胞生成抑制所致。对骨髓和外周血红细胞祖细胞的体外检测显示，细胞数量正常，但当向培养物中加入自体血清或IgM时，细胞数量显著下降，而加入自体IgG或去除IgM的自体血清时细胞数量保持不变。与儿童“暂时性”成红细胞减少症不同，这种贫血是复发性的，持续时间更长，且似乎对泼尼松有反应。
