Syrjänen K J
Surg Gynecol Obstet. 1980 Mar;150(3):372-6.
Histologic specimens from the uterine cervix of 169 women with an epithelial dysplasia or neoplasia were studied with special reference to condylomatous epithelial lesions. Histologic changes suggestive of the presence of the classical papillomatous condyloma or the newly discovered flat and inverted condylomas were found in 84 women, 49.7 per cent. Condylomatous lesions were associated with all degrees of epithelial changes from mild dysplasia to frankly invasive carcinoma of the uterine cervix. The mean age of the women with condylomatous lesions was significantly lower, p less than 0.001, than that for women without these lesions in the epithelium. Dysplasias in women less than 20 years of age were always associated with condylomatous changes, and 88.1 per cent of the condylomas were present in women less than 40 years of age. Condylomas most probably transmitted venereally are associated with dysplasias and neoplasias in a high percentage of patients. Under the coexistence of the condylomatous lesion, the dysplastic and neoplastic changes in the epithelium of the uterine cervix seem to develop at quite an early age.
对169例患有上皮发育异常或肿瘤的女性子宫颈组织学标本进行了研究，特别关注湿疣样上皮病变。在84名女性（占49.7%）中发现了提示存在经典乳头瘤样湿疣或新发现的扁平湿疣及内翻性湿疣的组织学变化。湿疣样病变与子宫颈上皮从轻度发育异常到明显浸润癌的所有程度的变化相关。有湿疣样病变的女性的平均年龄显著低于上皮无这些病变的女性，p<0.001。20岁以下女性的发育异常总是与湿疣样变化相关，88.1%的湿疣见于40岁以下女性。极有可能通过性传播的湿疣在高比例患者中与发育异常和肿瘤形成相关。在湿疣样病变共存的情况下，子宫颈上皮的发育异常和肿瘤性变化似乎在相当早的年龄就会发生。
