Condylomatous lesions in dysplastic and neoplastic epithelium of the uterine cervix.

Histologic specimens from the uterine cervix of 169 women with an epithelial dysplasia or neoplasia were studied with special reference to condylomatous epithelial lesions. Histologic changes suggestive of the presence of the classical papillomatous condyloma or the newly discovered flat and inverted condylomas were found in 84 women, 49.7 per cent. Condylomatous lesions were associated with all degrees of epithelial changes from mild dysplasia to frankly invasive carcinoma of the uterine cervix. The mean age of the women with condylomatous lesions was significantly lower, p less than 0.001, than that for women without these lesions in the epithelium. Dysplasias in women less than 20 years of age were always associated with condylomatous changes, and 88.1 per cent of the condylomas were present in women less than 40 years of age. Condylomas most probably transmitted venereally are associated with dysplasias and neoplasias in a high percentage of patients. Under the coexistence of the condylomatous lesion, the dysplastic and neoplastic changes in the epithelium of the uterine cervix seem to develop at quite an early age.