清醒家兔下丘脑血流间接胆碱能调节的证据。
Evidence for an indirect cholinergic regulation of blood flow in the hypothalamus of conscious rabbits.
作者信息
Klugman K, Mitchell G, Rosendorff C
出版信息
Br J Pharmacol. 1979 Jun;66(2):217-21. doi: 10.1111/j.1476-5381.1979.tb13668.x.
Abstract
1 The effects of methacholine, atropine and adrenoceptor blockade on hypothalamic blood flow (HBF) were measured in conscious rabbits. 2 A dose of 1 microgram methacholine increased HBF while smaller and larger doses had no significant effect. 3 The vasodilatation induced by methacholine was blocked by atropine and by chemical sympathectomy of the hypothalamus with 6-hydroxydopamine. 4 The vasodilatation was reversed by propranolol but was not affected by phenoxybenzamine. 5 These results suggest that the vasodilator action of muscarinic receptor agonists on hypothalamic resistance vessels depends upon the integrity of a noradrenergic system, and is mediated via beta-adrenoceptors.
摘要
- 在清醒家兔中测量了乙酰甲胆碱、阿托品和肾上腺素能受体阻断对下丘脑血流量（HBF）的影响。2. 1微克乙酰甲胆碱的剂量增加了HBF，而较小和较大剂量则无显著影响。3. 乙酰甲胆碱诱导的血管舒张被阿托品以及用6-羟基多巴胺对下丘脑进行化学交感神经切除术所阻断。4. 血管舒张被普萘洛尔逆转，但不受酚苄明影响。5. 这些结果表明，毒蕈碱受体激动剂对下丘脑阻力血管的血管舒张作用取决于去甲肾上腺素能系统的完整性，并通过β-肾上腺素能受体介导。
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