P物质通过间接的肾上腺素能-胆碱能相互作用增加下丘脑血流量。
Substance P increases hypothalamic blood flow via an indirect adrenergic-cholinergic interaction.
作者信息
Klugman K P, Lembeck F, Markowitz S, Mitchell G, Rosendorff C
出版信息
Br J Pharmacol. 1980;71(2):623-9. doi: 10.1111/j.1476-5381.1980.tb10982.x.
1 Hypothalamic blood flow (HBF) was measured in conscious rabbits by the 133xenon washout technique. 2 Substance P in a dose of 50 or 500 ng increases HBF while 5 ng is without effect. 3 Cholinoceptor blockade, with either atropine or mecamylamine abolishes the vasodilator effect of substance P. 4 Chemical sympathectomy of the hypothalamus with 6-hydroxydopamine, or adrenoceptor blockade with either propranolol or phenoxybenzamine abolishes the effect of substance P on HBF. 5 Destruction of the intracerebral noradrenergic pathway (INP), or blockade of its vasodilator action, with barbiturate or bicarbonate, likewise prevent the vasodilator action of substance P. 6 These results suggest that substance P may cause an increase in HBF via the release of endogenous acetylcholine, which in turn stimulates the INP.
采用¹³³氙清除技术，在清醒兔身上测量下丘脑血流量（HBF）。
50或500纳克剂量的P物质可增加HBF，而5纳克则无作用。
用阿托品或美加明进行胆碱能受体阻断可消除P物质的血管舒张作用。
用6-羟基多巴胺对下丘脑进行化学交感神经切除术，或用普萘洛尔或酚苄明进行肾上腺素能受体阻断，可消除P物质对HBF的作用。
用巴比妥酸盐或碳酸氢盐破坏脑内去甲肾上腺素能通路（INP）或阻断其血管舒张作用，同样可阻止P物质的血管舒张作用。
这些结果表明，P物质可能通过释放内源性乙酰胆碱导致HBF增加，而内源性乙酰胆碱反过来又刺激INP。
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