兔下丘脑的局部血流、脑血管自动调节及二氧化碳反应性
Local blood flow, cerebrovascular autoregulation and CO2 responsiveness in the rabbit hypothalamus.
作者信息
Cranston W I, Rosendorff C
出版信息
J Physiol. 1971 Jul;215(3):577-90. doi: 10.1113/jphysiol.1971.sp009486.
Abstract
- Local blood flow has been measured in the hypothalamus and other areas of the brain in the conscious rabbit, by measuring the rate of clearance of small volumes (2.5-10 mul.) of a saline solution of the inert tracer (133)Xe injected locally.2. Increasing the arterial P(CO2) caused a mean rise in the hypothalamic blood flow of 34%.3. The hypothalamic blood flow remained relatively constant over a mean arterial blood pressure range of 41-140 mm Hg.4. Hypothalamic blood flow was relatively unaffected by anaesthesia with intravenous pentobarbitone; by contrast, blood flow in the cerebral cortex was greatly reduced.5. It is concluded that the technique is a valid and useful one, since CO(2) responsiveness and autoregulation is maintained. Different areas of grey matter have different flow rates, and vary in their responsiveness to barbiturate anaesthesia.
摘要
通过测量局部注射惰性示踪剂（133）Xe的小体积（2.5 - 10微升）盐溶液的清除率，在清醒家兔的下丘脑及大脑其他区域测量了局部血流。
动脉血二氧化碳分压升高导致下丘脑血流平均增加34%。
在平均动脉血压范围为41 - 140毫米汞柱时，下丘脑血流保持相对恒定。
静脉注射戊巴比妥麻醉对下丘脑血流影响相对较小；相比之下，大脑皮质的血流则大幅减少。
得出的结论是，该技术是有效且有用的，因为二氧化碳反应性和自动调节功能得以维持。不同灰质区域的血流速率不同，对巴比妥类麻醉的反应也有所不同。
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本文引用的文献
1
Blood flow and oxygen consumption of the human brain during anesthesia produced by thiopental.
Anesthesiology. 1951 May;12(3):308-14. doi: 10.1097/00000542-195105000-00006.
2
AUTOREGULATION OF CEREBRAL BLOOD FLOW.脑血流的自动调节
Circ Res. 1964 Aug;15:SUPPL:201-4.
3
REGIONAL CEREBRAL BLOOD FLOW IN MAN DETERMINED BY KRYPTON.用氪测定人体局部脑血流量。
Neurology. 1963 Sep;13:719-27. doi: 10.1212/wnl.13.9.719.
4
The action of drugs on the cerebral circulation.药物对脑循环的作用。
Pharmacol Rev. 1959 Mar;11(1):1-85.
5
Effect of temperature on PCO2 and PO2 of blood in vitro.温度对体外血液PCO₂和PO₂的影响。
J Appl Physiol. 1956 Sep;9(2):201-4. doi: 10.1152/jappl.1956.9.2.201.
6
Coma mechanisms.昏迷机制
Am J Med. 1953 Dec;15(6):804-12. doi: 10.1016/0002-9343(53)90172-7.
7
The effect of carbon dioxide on cerebral blood flow, spinal fluid pressure and brain volume during pentothal sodium anesthesia.硫喷妥钠麻醉期间二氧化碳对脑血流量、脑脊液压力和脑容量的影响。
Curr Res Anesth Analg. 1953 Jul-Aug;32(4):268-73.
8
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Am J Med. 1953 Aug;15(2):171-4. doi: 10.1016/0002-9343(53)90067-9.
9
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10
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