医院致病性大肠菌群细菌中对甲氧苄啶耐药性的暴发。
Hospital outbreak of trimethoprim resistance in pathogenic coliform bacteria.
作者信息
Grüneberg R N, Bendall M J
出版信息
Br Med J. 1979 Jul 7;2(6181):7-9. doi: 10.1136/bmj.2.6181.7.
In an investigation of outbreak of infection caused by coliform bacilli with plasmid-mediated trimethoprim (TMP) resistance many patients were found to be asymptomatic carriers of TMP-resistant coliform bacilli. Analysis of factors predisposing to rectal carriage of these organisms showed that the most important was previous treatment with co-trimoxazole, a sulphonamide, or ampicillin. The outbreak was controlled by a policy restricting the antibiotics given. Geriatric units are an important source of hospital infection. When an outbreak occurs the logical sequence of steps to be taken is to monitor cases, identify the outbreaks, analyse the causative factors, plan corrective action jointly with laboratory staff, and monitor the outcome.
在一项关于由质粒介导的对甲氧苄啶（TMP）耐药的大肠埃希菌引起的感染暴发调查中，发现许多患者是TMP耐药大肠埃希菌的无症状携带者。对这些细菌在直肠定植的易感因素分析表明，最重要的是先前使用复方新诺明、一种磺胺类药物或氨苄西林进行治疗。通过限制使用抗生素的政策控制了此次暴发。老年病房是医院感染的一个重要来源。当暴发发生时，应采取的合理步骤顺序是监测病例、识别暴发、分析致病因素、与实验室工作人员共同制定纠正措施，并监测结果。
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