1978 - 1979年与1973 - 1975年相比对甲氧苄啶的耐药性。
Resistance to trimethoprim in 1978-79 compared with 1973-75.
作者信息
Hamilton-Miller J M, Gooding A, Brumfitt W
出版信息
J Clin Pathol. 1981 Apr;34(4):439-42. doi: 10.1136/jcp.34.4.439.
Abstract
The incidence of resistance to trimethoprim among urinary isolates between October 1978 and November 1979 was 11.5%, more than double the figure found April 1973 and October 1975. Of the resistant strains, 60% had a minimum inhibitory concentration in excess of 1 mg/ml. Escherichia coli and Proteus mirabilis showed the greatest increase in resistance since the previous study. Rather wide fluctuations occurred in the incidence of resistance for various species when the figures were analysed over two-month periods, hence studies of short duration must be interpreted with caution. There are not yet enough data from this or other studies for the cause of the increased incidence of resistance to trimethoprim to be determined.
摘要
1978年10月至1979年11月期间，尿液分离株对甲氧苄啶的耐药率为11.5%，是1973年4月至1975年10月期间所发现数字的两倍多。在耐药菌株中，60%的最低抑菌浓度超过1毫克/毫升。自上次研究以来，大肠杆菌和奇异变形杆菌的耐药性增加最为显著。当按两个月的时间段分析各菌种的耐药率时，出现了相当大的波动，因此对短期研究的结果必须谨慎解读。目前，无论是本研究还是其他研究，都没有足够的数据来确定甲氧苄啶耐药率上升的原因。
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