Barasi S
Brain Res. 1979 Jul 27;171(1):121-30. doi: 10.1016/0006-8993(79)90737-6.
Experiments were performed to determine whether substantia nigra neurones respond to noxious stimulation. Some nigral neurones were found to respond to both noxious radiant heat and intra-arterially administered bradykinin. Most nociceptive neurones were excited by noxious stimulation although some exhibited a reduction in firing rate. Following the injection of bradykinin, responses to noxious heat were reduced in magnitude for periods of up to an hour. These results show that some nigral neurones are nociceptive and provide further support for the suggestion that dopamine is involved in nociceptive mechanisms. In addition it is suggested that bradykinin may represent a rather gross of non-specific form of noxious stimulation.
进行了实验以确定黑质神经元是否对伤害性刺激产生反应。发现一些黑质神经元对伤害性辐射热和动脉内注射缓激肽均有反应。大多数伤害感受神经元受到伤害性刺激而兴奋，尽管有些神经元的放电频率降低。注射缓激肽后，对伤害性热的反应在长达一小时的时间内幅度减小。这些结果表明，一些黑质神经元具有伤害感受性，并为多巴胺参与伤害感受机制的观点提供了进一步支持。此外，有人提出缓激肽可能代表一种相当粗略的非特异性伤害性刺激形式。
