Pay Sharon, Barasi S
Department of Physiology, University College, P.O. Box 78, Cardiff CFI IXLGreat Britain.
Pain. 1982 Jan;12(1):75-89. doi: 10.1016/0304-3959(82)90171-3.
(i) Of 226 spontaneously active neurones recorded from the substantia nigra (SN) of rats anaesthetised with halothane, 112 (50%) were found to be nociceptive. (ii) Nociceptive neurones were located in both the zona compacta (ZC) and zona reticulata (ZR) compartments of the SN. (iii) Using the collision-test technique it has been shown that approximately equal proportions of nociceptive and non-nociceptive SN neurones project to the thalamus. The majority of nigrostriatal neurones were found to be non-nociceptive. In contrast striatonigral and amygdalonigral afferents are more likely to influence nociceptive than non-nociceptive SN neurones. (iv) Experiments were performed to determine whether nociceptive SN neurones were dopaminergic. Examination of spontaneous firing rate, action potential configuration and responses to systemically administered dopaminomimetic agents of histologically identified SN neurones did not allow a reliable distinction to be made between dopaminergic and non-dopaminergic neurones. It was therefore not possible to resolve this question.
(i) 在用氟烷麻醉的大鼠黑质（SN）中记录到的226个自发活动神经元中，发现112个（50%）是伤害性感受神经元。(ii) 伤害性感受神经元位于黑质的致密部（ZC）和网状部（ZR）区域。(iii) 使用碰撞测试技术表明，投射到丘脑的伤害性感受和非伤害性感受的SN神经元比例大致相等。大多数黑质纹状体神经元被发现是非伤害性感受的。相比之下，纹状体黑质和杏仁核黑质传入纤维更有可能影响伤害性感受的SN神经元而非非伤害性感受的SN神经元。(iv) 进行实验以确定伤害性感受的SN神经元是否为多巴胺能神经元。对组织学鉴定的SN神经元的自发放电率、动作电位形态以及对全身给予拟多巴胺药物的反应进行检查，无法可靠地区分多巴胺能和非多巴胺能神经元。因此，无法解决这个问题。
