核酸中呋喃糖环的尺寸和形状。
The dimensions and shapes of the furanose rings in nucleic acids.
作者信息
Arnott S, Hukins D W
出版信息
Biochem J. 1972 Nov;130(2):453-65. doi: 10.1042/bj1300453.
Abstract
A survey was made of the geometry of furanose rings in beta-nucleotides and beta-nucleosides (as monomers related to nucleic acids) for which structures have been determined by X-ray crystallography. Mean values, and estimated standard deviations from them, were calculated for bond-lengths, bond-angles and conformation-angles. For parameters with values dependent on ring-puckering, separate calculations were made for each ring type. (The rings are puckered in one of three conformations: C-2- or C-3-endo or C-3-exo; C-2-exo has not been observed.) The results were used to compute standard furanose rings with C-2-endo, C-3-endo and C-3-exo conformations for use in nucleic acid molecular model-building. The survey also showed that the only other conformation-angle in nucleotides dependent on the furanose ring conformation corresponds to the relative orientation of the purine (or pyrimidine) base and the ring.
摘要
对β-核苷酸和β-核苷（作为与核酸相关的单体）中的呋喃糖环几何结构进行了一项调查，这些结构已通过X射线晶体学确定。计算了键长、键角和构象角的平均值以及与其估计的标准偏差。对于值取决于环褶皱的参数，对每种环类型进行了单独计算。（环以三种构象之一发生褶皱：C-2-或C-3-内型或C-3-外型；未观察到C-2-外型。）结果用于计算具有C-2-内型、C-3-内型和C-3-外型构象的标准呋喃糖环，以用于核酸分子模型构建。该调查还表明，核苷酸中唯一另一个取决于呋喃糖环构象的构象角对应于嘌呤（或嘧啶）碱基与环的相对取向。
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