Grimelius L, Hultquist G T, Stenkvist B
Virchows Arch A Pathol Anat Histol. 1975;365(4):275-88. doi: 10.1007/BF00471177.
In eleven cases thirteen pancreatic islet cell adenomas were found in autopsy material from 1366 adult cases. Ten of the adenomas were solitary, while 3 small adenomas were observed in a single case. Another four possible solitary adenomas were observed, but their identity was uncertain owing to marked fibrosis. All the adenomas contained A-2 (A)-1 cells but no B (B)-1 cells. Nine of them also contained A-1 (D)-1 cells. The majority of cells in the adenomas were A-2 cells or cells which did not stain with any of the techniques used. The 4 possible adenomas contained islet cells (A-1, A-2, B) in different proportions. With one exception the patients with adenomas and possible adenomas were 65 years of age or older, and in some of these cases adenomas or hyperplasias were also found in other endocrine organs. The frequency of gastroduodenal ulcers or scars in the cases with adenoma or possible adenoma did not differ notably from that found in the cases without pancreatic adenomas. Among the cases with pancreatic adenoma and possible adenoma there were 3 patients with maturity onset diabetes mellitus, but otherwise no clinical symptoms of endocrine disturbances were noted.
在1366例成人尸检材料中，11例发现了13个胰岛细胞瘤。其中10个腺瘤为单发，1例中观察到3个小腺瘤。另外还观察到4个可能为单发的腺瘤，但由于明显纤维化，其性质不确定。所有腺瘤均含有A - 2（A）- 1细胞，但无B（B）- 1细胞。其中9个还含有A - 1（D）- 1细胞。腺瘤中的大多数细胞为A - 2细胞或用所采用的任何技术均不着色的细胞。4个可能的腺瘤含有不同比例的胰岛细胞（A - 1、A - 2、B）。除1例例外，患有腺瘤和可能腺瘤的患者年龄均在65岁及以上，其中一些病例在其他内分泌器官中也发现了腺瘤或增生。腺瘤或可能腺瘤患者中胃十二指肠溃疡或瘢痕的发生率与无胰腺腺瘤患者中发现的发生率无明显差异。在患有胰腺腺瘤和可能腺瘤的病例中，有3例患有成年型糖尿病，但除此之外未发现内分泌紊乱的临床症状。
