Pitchumoni C S, Thelmo W, Ahmed K S, Kumar A, Davidian M, Einhorn R, Adler J, McCarthy J
J Clin Gastroenterol. 1979 Sep;1(3):219-23. doi: 10.1097/00004836-197909000-00005.
A 53-year-old white woman developed diabetes mellitus, migratory erythema, and anemia, clinical features suggesting the presence of a "glucagonoma." Ten years earlier, after laparotomy and pancreatic biopsy, she had been told that she had an inoperable pancreatic carcinoma. Review of that biopsy together with current hormonal assay now confirms the diagnosis of glucagonoma. The recurrent peptic ulcer in this patient despite high levels of glucagon, a gastric inhibitory agent, is noted but not explained. An enhanced amylase-creatinine clearance ratio supports the notion that glucagon increases the clearances of amylase.
一名53岁的白人女性出现了糖尿病、游走性红斑和贫血，这些临床特征提示存在“胰高血糖素瘤”。十年前，她接受剖腹手术和胰腺活检后，被告知患有无法手术切除的胰腺癌。对那次活检结果以及当前激素检测结果的复查现在证实了胰高血糖素瘤的诊断。尽管该患者体内存在高水平的胰高血糖素（一种胃抑制因子），但仍出现复发性消化性溃疡，这一点值得注意但未得到解释。淀粉酶 - 肌酐清除率升高支持了胰高血糖素会增加淀粉酶清除率这一观点。
