猪血浆中苄胺氧化酶的催化机制。
A catalytic mechanism for the enzyme benzylamine oxidase from pig plasma.
作者信息
Taylor C E, Taylor R S, Rasmussen C, Knowles P F
出版信息
Biochem J. 1972 Dec;130(3):713-28. doi: 10.1042/bj1300713.
Abstract
Initial-velocity and product-inhibition studies on the enzyme benzylamine oxidase from pig plasma indicate that the order of substrate addition and product release is benzylamine on, ammonia off, oxygen on, hydrogen peroxide off, benzaldehyde off. Ammonia, but not benzaldehyde, is released under strictly anaerobic conditions which provides independent evidence for this order. Benzyl alcohol is a substrate for the enzyme. A chemical mechanism consistent with all the data is proposed.
摘要
对猪血浆中苄胺氧化酶的初速度和产物抑制研究表明，底物添加和产物释放的顺序是苄胺进入、氨释放、氧气进入、过氧化氢释放、苯甲醛释放。在严格厌氧条件下会释放氨，但不会释放苯甲醛，这为该顺序提供了独立证据。苄醇是该酶的一种底物。提出了一种与所有数据一致的化学机制。
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