Muztar A J, Huque T, Ahmad P, Slinger S J
Can J Physiol Pharmacol. 1979 May;57(5):504-9. doi: 10.1139/y79-076.
Allyl isothiocyanate (AITC) is a constituent of several plants of the family Cruciferae that are commonly used as food. This study investigated the effect of feeding AITC to male Sprague-Dawley rats on their plasma glucose and uric acid levels as well as on the urinary concentrations of glucose, 17-ketosteroids (17-KS), creatinine, and uric acid. Other test compounds included were thyroxine (T4) and thiouracil (TU). AITC caused a highly significant (P smaller than or equal to 0.01) depression in the plasma glucose and uric acid levels compared with the control. TU caused a significant depression only of the plasma glucose. T4, on the other hand, significantly increased the levels of both glucose and uric acid. The AITC-treated rats voided twice as much urine as the controls or those receiving TU or injected with T4. The 24-h excretion of glucose, uric acid, and creatinine was significantly (P smaller than or equal to 0.01) higher in animals fed AITC than in those consuming the control diet, while the excretion of 17-KS was significantly lower. Results on an equal urine volume basis showed that differences in the excretion of glucose and creatinine were related to differences in the urine volume. TU significantly depressed excretion of all the compounds but glucose. The effect of T4 on the excretion of 17-KS and uric acid resembled that of AITC and TU, thus showing that these compounds depressed the androgenic function of the animal.
烯丙基异硫氰酸酯（AITC）是十字花科几种常用作食物的植物的一种成分。本研究调查了给雄性斯普拉格-道利大鼠喂食 AITC 对其血糖和尿酸水平以及尿液中葡萄糖、17-酮类固醇（17-KS）、肌酐和尿酸浓度的影响。其他受试化合物包括甲状腺素（T4）和硫脲（TU）。与对照组相比，AITC 导致血浆葡萄糖和尿酸水平高度显著降低（P≤0.01）。TU 仅导致血浆葡萄糖显著降低。另一方面，T4 显著提高了葡萄糖和尿酸水平。接受 AITC 处理的大鼠排尿量是对照组、接受 TU 处理的大鼠或注射 T4 的大鼠的两倍。喂食 AITC 的动物 24 小时内葡萄糖、尿酸和肌酐的排泄量显著高于（P≤0.01）食用对照饮食的动物，而 17-KS 的排泄量显著更低。基于等尿量的结果表明，葡萄糖和肌酐排泄量的差异与尿量差异有关。TU 显著降低了除葡萄糖外所有化合物的排泄量。T4 对 17-KS 和尿酸排泄的影响与 AITC 和 TU 相似，因此表明这些化合物抑制了动物的雄激素功能。
