加拿大抗血友病因子制剂的一项临床试验报告。

Report of a clinical trial of a Canadian preparation of antihemophilic factor.

作者信息

Magnin A A, Johnson S E

出版信息

Can Med Assoc J. 1979 Aug 18;121(4):422-4, 427.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1704378/

Abstract

A clinical trial of a Canadian preparation of antihemophilic factor has been completed. The mean percentage increase in the factor VIII coagulant activity in the plasma was determined to be 2.1 +/- 0.8 per unit per kilogram dose, which compares very favourably with published data. The mean half-life of antihemophilic factor was found to be 14.7 hours. Side effects and reactions to the product were minimal and the product has been rated as clinically effective. No significant differences between lots were noted in the in vivo response or the half-life.

摘要

一项关于加拿大制备的抗血友病因子的临床试验已经完成。血浆中因子VIII凝血活性的平均百分比增加量经测定为每千克剂量每单位2.1±0.8，与已发表的数据相比非常有利。抗血友病因子的平均半衰期为14.7小时。该产品的副作用和反应极小，且已被评定为临床有效。各批次之间在体内反应或半衰期方面未发现显著差异。

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本文引用的文献

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