Kar N C, Pearson C M
Clin Chim Acta. 1979 Jun 15;94(3):277-80. doi: 10.1016/0009-8981(79)90076-7.
The level of thiobarbituric acid-reactive products and the specific activities of catalase and glutathione reductase were significantly higher in muscles from patients with major forms of muscular dystrophies over those of control subjects. Superoxide dismutase activity was not altered in dystrophic muscles. These findings indicate the occurrence in human dystrophic muscles of an increased level of lipid peroxidation and the possible activation of certain enzymes that could conceivably inhibit lipid peroxidation in vivo.
在患有主要类型肌营养不良症的患者肌肉中，硫代巴比妥酸反应产物水平以及过氧化氢酶和谷胱甘肽还原酶的比活性显著高于对照组。在营养不良的肌肉中，超氧化物歧化酶活性未发生改变。这些发现表明，人类营养不良肌肉中脂质过氧化水平升高，并且某些酶可能被激活，这些酶在体内可能抑制脂质过氧化。
