Metcalf M G, Livesey J H
Clin Chim Acta. 1979 Jun 15;94(3):287-93. doi: 10.1016/0009-8981(79)90078-0.
The increased gonadotrophin secretion which occurs at the menopause was followed by measuring gonadotrophin to creatinine ratios in small samples of urine. For follicle stimulating hormone, values of the ratio corresponded closely with both plasma concentration (correlation coefficients: 0.93, 0.94 and 0.93 for first morning, mid-morning and mid-afternoon urine samples: all results expressed as logarithms) and 24-h urine output (0.98, 0.96 and 0.94). Comparable figures for luteinising hormone (LH) were 0.94, 0.94 and 0.90; and 0.95, 0.95 and 0.90. Multiplication of the gonadotrophin to creatinine ratios (I.U./mmol) by 10 gave a figure close to 24-h gonadotrophin output (I.U.).
在绝经后出现促性腺激素分泌增加的情况后，通过测量少量尿样中促性腺激素与肌酐的比值来进行研究。对于促卵泡激素，该比值与血浆浓度密切相关（晨尿、上午中段尿和下午中段尿样本的相关系数分别为0.93、0.94和0.93：所有结果均以对数表示），也与24小时尿量密切相关（分别为0.98、0.96和0.94）。促黄体生成素（LH）的可比数据分别为0.94、0.94和0.90；以及0.95、0.95和0.90。将促性腺激素与肌酐的比值（国际单位/毫摩尔）乘以10得到的数值接近24小时促性腺激素的分泌量（国际单位）。
