Dienstag J, Neu H C
Antimicrob Agents Chemother. 1972 Jan;1(1):41-5. doi: 10.1128/AAC.1.1.41.
Tobramycin is an aminoglycoside antibiotic which has excellent antibacterial activity against Pseudomonas, Staphylococcus aureus, and many members of the Enterobacteriaceae. Most strains of Serratia, Providence, Streptococcus, and Diplococcus pneumoniae were resistant to concentrations of tobramycin which could be achieved in man. Tobramycin was effective against certain Pseudomonas strains resistant to gentamicin. The growth medium used to determine the inhibitory level of tobramycin had a significant effect upon the minimal inhibitory concentration. Calcium and magnesium ions inhibited the bactericidal effect of tobramycin. Tobramycin and carbenicillin acted in a synergistic manner. Ethylenediaminetetraacetic acid did not act in a synergistic manner with tobramycin. Broth-dilution susceptibility tests and disc-diffusion tests in agar (10-mug discs) showed excellent correlation except with Proteus strains.
妥布霉素是一种氨基糖苷类抗生素，对铜绿假单胞菌、金黄色葡萄球菌以及许多肠杆菌科细菌具有出色的抗菌活性。大多数沙雷氏菌、普罗威登斯菌、链球菌和肺炎双球菌菌株对人体能够达到的妥布霉素浓度具有耐药性。妥布霉素对某些对庆大霉素耐药的铜绿假单胞菌菌株有效。用于确定妥布霉素抑制水平的生长培养基对最低抑菌浓度有显著影响。钙和镁离子会抑制妥布霉素的杀菌作用。妥布霉素和羧苄青霉素具有协同作用。乙二胺四乙酸与妥布霉素不具有协同作用。肉汤稀释药敏试验和琼脂平板扩散试验（10微克纸片）显示，除变形杆菌菌株外，二者具有良好的相关性。
