新型氨基糖苷类抗生素BB-K8的体外研究
In vitro studies of BB-K8, a new aminoglycoside antibiotic.
作者信息
Bodey G P, Stewart D
出版信息
Antimicrob Agents Chemother. 1973 Aug;4(2):186-92. doi: 10.1128/AAC.4.2.186.
Abstract
BB-K8, an aminoglycoside antibiotic which is a derivative of kanamycin, was tested in vitro against 466 clinical bacterial isolates. Over 90% of gram-negative bacilli, except Proteus spp., were inhibited by 3.12 mug of BB-K8 per ml. This antibiotic was consistently more active than kanamycin but less active than tobramycin or gentamicin. Unlike kanamycin, BB-K8 was active against Pseudomonas aeruginosa. Eleven of 19 isolates resistant to either gentamicin or tobramycin, or both, were susceptible to BB-K8.
摘要
BB-K8是一种氨基糖苷类抗生素，是卡那霉素的衍生物，对466株临床分离细菌进行了体外测试。除变形杆菌属外，超过90%的革兰氏阴性杆菌被每毫升3.12微克的BB-K8抑制。这种抗生素始终比卡那霉素活性更强，但比妥布霉素或庆大霉素活性弱。与卡那霉素不同，BB-K8对铜绿假单胞菌有活性。对庆大霉素或妥布霉素或两者耐药的19株分离菌中有11株对BB-K8敏感。
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